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Protocol design and synopsis: Omalizumab as Monotherapy and as Adjunct Therapy to Multiallergen OIT in Children and Adults with Food Allergy (OUtMATCH).
Wood RA, Chinthrajah RS, Rudman Spergel AK, Babineau DC, Sicherer SH, Kim EH, Shreffler WG, Jones SM, Leung DYM, Vickery BP, Bird JA, Spergel JM, Kulis M, Iqbal A, Kaufman D, Umetsu DT, Ligueros-Saylan M, Uddin A, Fogel RB, Lussier S, Mudd K, Poyser J, MacPhee M, Veri M, Davidson W, Hamrah S, Long A, Togias A; OUtMATCH study team. Wood RA, et al. Among authors: long a. J Allergy Clin Immunol Glob. 2022 Jul 21;1(4):225-232. doi: 10.1016/j.jacig.2022.05.006. eCollection 2022 Nov. J Allergy Clin Immunol Glob. 2022. PMID: 37779534 Free PMC article.
Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial.
Andorf S, Purington N, Block WM, Long AJ, Tupa D, Brittain E, Rudman Spergel A, Desai M, Galli SJ, Nadeau KC, Chinthrajah RS. Andorf S, et al. Among authors: long aj. Lancet Gastroenterol Hepatol. 2018 Feb;3(2):85-94. doi: 10.1016/S2468-1253(17)30392-8. Epub 2017 Dec 12. Lancet Gastroenterol Hepatol. 2018. PMID: 29242014 Free PMC article. Clinical Trial.
The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses.
Sindher SB, Long A, Acharya S, Sampath V, Nadeau KC. Sindher SB, et al. Among authors: long a. Clin Rev Allergy Immunol. 2018 Oct;55(2):190-204. doi: 10.1007/s12016-018-8678-z. Clin Rev Allergy Immunol. 2018. PMID: 29455358 Free PMC article. Review.
The incidence of allergic conditions has continued to rise over the past several decades, with a growing body of research dedicated toward the treatment of such conditions. By driving a complex range of changes in the underlying immune response, immunotherapy is the …
The incidence of allergic conditions has continued to rise over the past several decades, with a growing body of research dedicated t …
Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges.
Purington N, Chinthrajah RS, Long A, Sindher S, Andorf S, O'Laughlin K, Woch MA, Scheiber A, Assa'ad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Desai M, Nadeau KC. Purington N, et al. Among authors: long a. Front Immunol. 2018 Sep 21;9:2057. doi: 10.3389/fimmu.2018.02057. eCollection 2018. Front Immunol. 2018. PMID: 30298065 Free PMC article. Clinical Trial.
Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.
Sindher S, Long AJ, Purington N, Chollet M, Slatkin S, Andorf S, Tupa D, Kumar D, Woch MA, O'Laughlin KL, Assaad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Nadeau KC, Chinthrajah RS. Sindher S, et al. Among authors: long aj. Front Immunol. 2018 Nov 27;9:2689. doi: 10.3389/fimmu.2018.02689. eCollection 2018. Front Immunol. 2018. PMID: 30538699 Free PMC article.
A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals.
Andorf S, Purington N, Kumar D, Long A, O'Laughlin KL, Sicherer S, Sampson H, Cianferoni A, Whitehorn TB, Petroni D, Makhija M, Robison RG, Lierl M, Logsdon S, Desai M, Galli SJ, Rael E, Assa'ad A, Chinthrajah S, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Nadeau K. Andorf S, et al. Among authors: long a. EClinicalMedicine. 2019 Jan 21;7:27-38. doi: 10.1016/j.eclinm.2018.12.006. eCollection 2019 Jan. EClinicalMedicine. 2019. PMID: 31193674 Free PMC article.
Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study.
Chinthrajah RS, Purington N, Andorf S, Long A, O'Laughlin KL, Lyu SC, Manohar M, Boyd SD, Tibshirani R, Maecker H, Plaut M, Mukai K, Tsai M, Desai M, Galli SJ, Nadeau KC. Chinthrajah RS, et al. Among authors: long a. Lancet. 2019 Oct 19;394(10207):1437-1449. doi: 10.1016/S0140-6736(19)31793-3. Epub 2019 Sep 12. Lancet. 2019. PMID: 31522849 Free PMC article. Clinical Trial.
We evaluated the sustained effects of peanut allergy oral immunotherapy (OIT) in a randomised long-term study in adults and children. METHODS: In this randomised, double-blind, placebo-controlled, phase 2 study, we enrolled participants at the Sean N Parker Center f …
We evaluated the sustained effects of peanut allergy oral immunotherapy (OIT) in a randomised long-term study in adults and ch …
Conflicting verdicts on peanut oral immunotherapy from the Institute for Clinical and Economic Review and US Food and Drug Administration Advisory Committee: Where do we go from here?
Eiwegger T, Anagnostou K, Arasi S, Bégin P, Ben-Shoshan M, Beyer K, Blumchen K, Brough H, Caubet JC, Chan ES, Chen M, Chinthrajah S, Davis CM, Des Roches A, Du Toit G, Elizur A, Galli SJ, Håland G, Hoffmann-Sommergruber K, Kim H, Leung DYM, Long A, Muraro A, Nurmatov UB, Pajno GB, Sampath V, Saxena J, Sindher S, Upton J, Worm M, Nadeau KC. Eiwegger T, et al. Among authors: long a. J Allergy Clin Immunol. 2020 Apr;145(4):1153-1156. doi: 10.1016/j.jaci.2019.10.021. Epub 2019 Nov 1. J Allergy Clin Immunol. 2020. PMID: 31678426 No abstract available.
New Developments in Non-allergen-specific Therapy for the Treatment of Food Allergy.
Long A, Borro M, Sampath V, Chinthrajah RS. Long A, et al. Curr Allergy Asthma Rep. 2020 Jan 16;20(1):3. doi: 10.1007/s11882-020-0897-8. Curr Allergy Asthma Rep. 2020. PMID: 31950290 Review.
At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of durability of desensi …
At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods …
1,920 results