A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609.
Tokumitsu H, Inuzuka H, Ishikawa Y, Kobayashi R.
Tokumitsu H, et al. Among authors: inuzuka h.
J Biol Chem. 2003 Mar 28;278(13):10908-13. doi: 10.1074/jbc.M213183200. Epub 2003 Jan 22.
J Biol Chem. 2003.
PMID: 12540834
Free article.
We recently developed STO-609, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase kinase (CaM-KK), and we demonstrated that CaM-KK beta is more sensitive to STO-609 than the CaM-KK alpha isoform (Tokumitsu H., Inuzuka H., Ishikawa Y., Ikeda M …
We recently developed STO-609, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase kinase (CaM-KK), and we demonstrated that …