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Page 1
Acetylation reprograms MITF target selectivity and residence time.
Louphrasitthiphol P, Loffreda A, Pogenberg V, Picaud S, Schepsky A, Friedrichsen H, Zeng Z, Lashgari A, Thomas B, Patton EE, Wilmanns M, Filippakopoulos P, Lambert JP, Steingrímsson E, Mazza D, Goding CR. Louphrasitthiphol P, et al. Among authors: filippakopoulos p. Nat Commun. 2023 Sep 28;14(1):6051. doi: 10.1038/s41467-023-41793-7. Nat Commun. 2023. PMID: 37770430 Free PMC article.
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.
Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CR. Ngeow KC, et al. Among authors: filippakopoulos p. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8668-E8677. doi: 10.1073/pnas.1810498115. Epub 2018 Aug 27. Proc Natl Acad Sci U S A. 2018. PMID: 30150413 Free PMC article.
Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.
Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR. Louphrasitthiphol P, et al. Among authors: filippakopoulos p. Mol Cell. 2020 Aug 6;79(3):472-487.e10. doi: 10.1016/j.molcel.2020.05.025. Epub 2020 Jun 11. Mol Cell. 2020. PMID: 32531202 Free PMC article.
Emerging tools to investigate bromodomain functions.
Kougnassoukou Tchara PE, Filippakopoulos P, Lambert JP. Kougnassoukou Tchara PE, et al. Among authors: filippakopoulos p. Methods. 2020 Dec 1;184:40-52. doi: 10.1016/j.ymeth.2019.11.003. Epub 2019 Nov 11. Methods. 2020. PMID: 31726225 Review.
SPOTing Acetyl-Lysine Dependent Interactions.
Picaud S, Filippakopoulos P. Picaud S, et al. Among authors: filippakopoulos p. Microarrays (Basel). 2015 Aug 17;4(3):370-88. doi: 10.3390/microarrays4030370. Microarrays (Basel). 2015. PMID: 27600229 Free PMC article.
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P. Savitsky P, et al. Among authors: filippakopoulos p. Cell Rep. 2016 Dec 6;17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014. Cell Rep. 2016. PMID: 27926874 Free PMC article.
Selective inhibition of BET bromodomains.
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73. doi: 10.1038/nature09504. Epub 2010 Sep 24. Nature. 2010. PMID: 20871596 Free PMC article.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC. Lambert JP, et al. Among authors: filippakopoulos p. Mol Cell. 2019 Feb 7;73(3):621-638.e17. doi: 10.1016/j.molcel.2018.11.006. Epub 2018 Dec 13. Mol Cell. 2019. PMID: 30554943 Free PMC article.
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Chen Z, Picaud S, Filippakopoulos P, D'Angiolella V, Bullock AN. Chen Z, et al. Among authors: filippakopoulos p. Structure. 2019 Sep 3;27(9):1395-1404.e4. doi: 10.1016/j.str.2019.06.005. Epub 2019 Jul 3. Structure. 2019. PMID: 31279627 Free PMC article.
96 results