Simons C - Search Results

1

Exploring Proteus mirabilis Methionine tRNA Synthetase Active Site: Homology Model Construction, Molecular Dynamics, Pharmacophore and Docking Validation.

Elbaramawi SS, Eissa AG, Noureldin NA, Simons C. Elbaramawi SS, et al. Among authors: simons c. Pharmaceuticals (Basel). 2023 Sep 6;16(9):1263. doi: 10.3390/ph16091263. Pharmaceuticals (Basel). 2023. PMID: 37765071 Free PMC article.

2

Exploring the binding sites of Staphylococcus aureus phenylalanine tRNA synthetase: A homology model approach.

Elbaramawi SS, Ibrahim SM, Lashine EM, El-Sadek ME, Mantzourani E, Simons C. Elbaramawi SS, et al. Among authors: simons c. J Mol Graph Model. 2017 May;73:36-47. doi: 10.1016/j.jmgm.2017.02.002. Epub 2017 Feb 10. J Mol Graph Model. 2017. PMID: 28235746

3

Design, Synthesis and Microbiological Evaluation of Novel Compounds as Potential Staphylococcus aureus Phenylalanine tRNA Synthetase Inhibitors.

Elbaramawi SS, Hughes C, Richards J, Gupta A, Ibrahim SM, Lashine EM, El-Sadek ME, O'Neill AJ, Wootton M, Bullard JM, Simons C. Elbaramawi SS, et al. Among authors: simons c. Egypt J Chem. 2018 Nov-Dec;61(Conference Iss):9-25. doi: 10.21608/EJCHEM.2018.4070.1357. Egypt J Chem. 2018. PMID: 31937997 Free PMC article.

4

Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation.

Noureldin NA, Richards J, Kothayer H, Baraka MM, Eladl SM, Wootton M, Simons C. Noureldin NA, et al. Among authors: simons c. RSC Adv. 2022 Jan 20;12(4):2511-2524. doi: 10.1039/d1ra06439h. eCollection 2022 Jan 12. RSC Adv. 2022. PMID: 35425259 Free PMC article.

5

Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives.

Eissa AG, Blaxland JA, Williams RO, Metwally KA, El-Adl SM, Lashine el-SM, Baillie LW, Simons C. Eissa AG, et al. Among authors: simons c. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1694-7. doi: 10.3109/14756366.2016.1140754. Epub 2016 Feb 22. J Enzyme Inhib Med Chem. 2016. PMID: 26899668 Free article.

6

Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues.

Noureldin NA, Richards J, Kothayer H, Baraka MM, Eladl SM, Wootton M, Simons C. Noureldin NA, et al. Among authors: simons c. BMC Chem. 2021 Oct 28;15(1):58. doi: 10.1186/s13065-021-00785-8. BMC Chem. 2021. PMID: 34711258 Free PMC article.

7

4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors.

Eissa AG, Barrow D, Gee J, Powell LE, Foster PA, Simons C. Eissa AG, et al. Among authors: simons c. Eur J Med Chem. 2022 Oct 5;240:114569. doi: 10.1016/j.ejmech.2022.114569. Epub 2022 Jul 6. Eur J Med Chem. 2022. PMID: 35834906 Free article.

8

Pyridine based dual binding site aromatase (CYP19A1) inhibitors.

Eissa AG, Powell LE, Gee J, Foster PA, Simons C. Eissa AG, et al. Among authors: simons c. RSC Med Chem. 2023 Jan 3;14(2):356-366. doi: 10.1039/d2md00352j. eCollection 2023 Feb 22. RSC Med Chem. 2023. PMID: 36846364 Free PMC article.

9

Targeting Mycobacterium tuberculosis: Synthesis, in vitro and in silico evaluation of novel N¹ -(benzo[d]oxazol-2-yl)-N⁴ -arylidine compounds.

Zawal AG, Abdel-Aziz MM, El-Shanawani AA, Abdel-Aziz LM, Taha M, Simons C, Elbaramawi SS. Zawal AG, et al. Among authors: simons c. Arch Pharm (Weinheim). 2023 Aug;356(8):e2300187. doi: 10.1002/ardp.202300187. Epub 2023 Jun 6. Arch Pharm (Weinheim). 2023. PMID: 37279375

10

Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.

Kishk SM, Kishk RM, Yassen ASA, Nafie MS, Nemr NA, ElMasry G, Al-Rejaie S, Simons C. Kishk SM, et al. Among authors: simons c. Molecules. 2020 Oct 29;25(21):5007. doi: 10.3390/molecules25215007. Molecules. 2020. PMID: 33137894 Free PMC article.

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