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Observing inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution.
Marx SK, Mickolajczyk KJ, Craig JM, Thomas CA, Pfeffer AM, Abell SJ, Carrasco JD, Franzi MC, Huang JR, Kim HC, Brinkerhoff H, Kapoor TM, Gundlach JH, Laszlo AH. Marx SK, et al. Among authors: kapoor tm. Nucleic Acids Res. 2023 Sep 22;51(17):9266-9278. doi: 10.1093/nar/gkad660. Nucleic Acids Res. 2023. PMID: 37560916 Free PMC article.
Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Jones NH, Liu Q, Urnavicius L, Dahan NE, Vostal LE, Kapoor TM. Jones NH, et al. Among authors: kapoor tm. Proc Natl Acad Sci U S A. 2024 Jun 11;121(24):e2316892121. doi: 10.1073/pnas.2316892121. Epub 2024 Jun 4. Proc Natl Acad Sci U S A. 2024. PMID: 38833472 Free PMC article.
Structure of the γ-tubulin ring complex-capped microtubule.
Aher A, Urnavicius L, Xue A, Neselu K, Kapoor TM. Aher A, et al. Among authors: kapoor tm. Nat Struct Mol Biol. 2024 Jul;31(7):1124-1133. doi: 10.1038/s41594-024-01264-z. Epub 2024 Apr 12. Nat Struct Mol Biol. 2024. PMID: 38609661
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: kapoor tm. J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22. J Am Chem Soc. 2024. PMID: 38134034 Free PMC article.
137 results