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Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates.
Izat N, Bolleddula J, Carione P, Huertas Valentin L, Jones RS, Kulkarni P, Moss D, Peterkin VC, Tian DD, Treyer A, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. CPT Pharmacometrics Syst Pharmacol. 2025 Jan;14(1):164-178. doi: 10.1002/psp4.13255. Epub 2024 Oct 23. CPT Pharmacometrics Syst Pharmacol. 2025. PMID: 39444174 Free PMC article.
Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. Drug Metab Dispos. 2023 Dec;51(12):1591-1606. doi: 10.1124/dmd.123.001436. Epub 2023 Sep 26. Drug Metab Dispos. 2023. PMID: 37751998