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Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. Among authors: houston jb. Drug Metab Dispos. 2023 Dec;51(12):1591-1606. doi: 10.1124/dmd.123.001436. Epub 2023 Sep 26. Drug Metab Dispos. 2023. PMID: 37751998
Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates.
Izat N, Bolleddula J, Carione P, Huertas Valentin L, Jones RS, Kulkarni P, Moss D, Peterkin VC, Tian DD, Treyer A, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. Among authors: houston jb. CPT Pharmacometrics Syst Pharmacol. 2025 Jan;14(1):164-178. doi: 10.1002/psp4.13255. Epub 2024 Oct 23. CPT Pharmacometrics Syst Pharmacol. 2025. PMID: 39444174 Free PMC article.
Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.
Price RJ, Scott MP, Cantrill C, Higgins LG, Moreau M, Yoon M, Clewell HJ, Creek MR, Osimitz TG, Houston JB, Lake BG. Price RJ, et al. Among authors: houston jb. Xenobiotica. 2021 Jan;51(1):40-50. doi: 10.1080/00498254.2020.1807075. Epub 2020 Aug 26. Xenobiotica. 2021. PMID: 32757971
The Critical Role of Passive Permeability in Designing Successful Drugs.
Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K. Di L, et al. Among authors: houston jb. ChemMedChem. 2020 Oct 19;15(20):1862-1874. doi: 10.1002/cmdc.202000419. Epub 2020 Sep 10. ChemMedChem. 2020. PMID: 32743945 Review.
261 results