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Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. Julien JP, et al. Among authors: doores kj. PLoS Pathog. 2013;9(5):e1003342. doi: 10.1371/journal.ppat.1003342. Epub 2013 May 2. PLoS Pathog. 2013. PMID: 23658524 Free PMC article.
Direct deprotected glycosyl-asparagine ligation.
Doores KJ, Mimura Y, Dwek RA, Rudd PM, Elliott T, Davis BG. Doores KJ, et al. Chem Commun (Camb). 2006 Apr 7;(13):1401-3. doi: 10.1039/b515472c. Epub 2006 Mar 6. Chem Commun (Camb). 2006. PMID: 16550280
Rewritable glycochips.
Harris LG, Schofield WC, Doores KJ, Davis BG, Badyal JP. Harris LG, et al. Among authors: doores kj. J Am Chem Soc. 2009 Jun 10;131(22):7755-61. doi: 10.1021/ja901294r. J Am Chem Soc. 2009. PMID: 19438244
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA. Kong L, et al. Among authors: doores kj. Nat Struct Mol Biol. 2013 Jul;20(7):796-803. doi: 10.1038/nsmb.2594. Epub 2013 May 26. Nat Struct Mol Biol. 2013. PMID: 23708606 Free PMC article.
119 results