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Page 1
Structural basis for CCR6 modulation by allosteric antagonists.
Wasilko DJ, Gerstenberger BS, Farley KA, Li W, Alley J, Schnute ME, Unwalla RJ, Victorino J, Crouse KK, Ding R, Sahasrabudhe PV, Vincent F, Frisbie RK, Dermenci A, Flick A, Choi C, Chinigo G, Mousseau JJ, Trujillo JI, Nuhant P, Mondal P, Lombardo V, Lamb D, Hogan BJ, Minhas GS, Segala E, Oswald C, Windsor IW, Han S, Rappas M, Cooke RM, Calabrese MF, Berstein G, Thorarensen A, Wu H. Wasilko DJ, et al. Among authors: unwalla rj. Nat Commun. 2024 Aug 31;15(1):7574. doi: 10.1038/s41467-024-52045-7. Nat Commun. 2024. PMID: 39217154 Free PMC article.
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Lees JA, Dias JM, Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG, Fisher EL, Tuttle JB, Lovett G, Kormos BL, Unwalla RJ, Zhang L, Dechert Schmitt AM, Zhou D, Moran M, Stevens KA, Fennell KF, Varghese AE, Maxwell A, Cote EE, Zhang Y, Han S. Lees JA, et al. Among authors: unwalla rj. Nat Commun. 2023 Sep 23;14(1):5938. doi: 10.1038/s41467-023-41646-3. Nat Commun. 2023. PMID: 37741852 Free PMC article.
Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions.
Yudt MR, Russo LA, Berrodin TJ, Jelinsky SA, Ellis D, Cohen JC, Cooch N, Haglund E, Unwalla RJ, Fensome A, Wrobel J, Zhang Z, Nagpal S, Winneker RC. Yudt MR, et al. Among authors: unwalla rj. Biochem Pharmacol. 2011 Dec 1;82(11):1709-19. doi: 10.1016/j.bcp.2011.08.006. Epub 2011 Aug 11. Biochem Pharmacol. 2011. PMID: 21854761
Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates.
Lundquist JT, Harnish DC, Kim CY, Mehlmann JF, Unwalla RJ, Phipps KM, Crawley ML, Commons T, Green DM, Xu W, Hum WT, Eta JE, Feingold I, Patel V, Evans MJ, Lai K, Borges-Marcucci L, Mahaney PE, Wrobel JE. Lundquist JT, et al. Among authors: unwalla rj. J Med Chem. 2010 Feb 25;53(4):1774-87. doi: 10.1021/jm901650u. J Med Chem. 2010. PMID: 20095622
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.
Pelletier JC, Lundquist JT 4th, Gilbert AM, Alon N, Bex FJ, Bhat BM, Bursavich MG, Coleburn VE, Felix LA, Green DM, Green P, Hauze DB, Kharode YP, Lam HS, Lockhead SR, Magolda RL, Matteo JJ, Mehlmann JF, Milligan C, Murrills RJ, Pirrello J, Selim S, Sharp MC, Unwalla RJ, Vera MD, Wrobel JE, Yaworsky P, Bodine PV. Pelletier JC, et al. Among authors: unwalla rj. J Med Chem. 2009 Nov 26;52(22):6962-5. doi: 10.1021/jm9014197. J Med Chem. 2009. PMID: 19856966
Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR).
Mehlmann JF, Crawley ML, Lundquist JT 4th, Unwalla RJ, Harnish DC, Evans MJ, Kim CY, Wrobel JE, Mahaney PE. Mehlmann JF, et al. Among authors: unwalla rj. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5289-92. doi: 10.1016/j.bmcl.2009.07.148. Epub 2009 Aug 3. Bioorg Med Chem Lett. 2009. PMID: 19683924
A new generation of progesterone receptor modulators.
Winneker RC, Fensome A, Zhang P, Yudt MR, McComas CC, Unwalla RJ. Winneker RC, et al. Among authors: unwalla rj. Steroids. 2008 Aug;73(7):689-701. doi: 10.1016/j.steroids.2008.03.005. Epub 2008 Mar 28. Steroids. 2008. PMID: 18472121 Review.
24 results