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The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance.
Lawson M, Cureton N, Ros S, Cheraghchi-Bashi A, Urosevic J, D'Arcy S, Delpuech O, DuPont M, Fisher DI, Gangl ET, Lewis H, Trueman D, Wali N, Williamson SC, Moss J, Montaudon E, Derrien H, Marangoni E, Miragaia RJ, Gagrica S, Morentin-Gutierrez P, Moss TA, Maglennon G, Sutton D, Polanski R, Rosen A, Cairns J, Zhang P, Sánchez-Guixé M, Serra V, Critchlow SE, Scott JS, Lindemann JPO, Barry ST, Klinowska T, Morrow CJ, Carnevalli LS. Lawson M, et al. Cancer Res. 2023 Dec 1;83(23):3989-4004. doi: 10.1158/0008-5472.CAN-23-0694. Cancer Res. 2023. PMID: 37725704 Free PMC article.
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
Scott JS, Stead D, Barlaam B, Breed J, Carbajo RJ, Chiarparin E, Cureton N, Davey PRJ, Fisher DI, Gangl ET, Grebe T, Greenwood RD, Hande S, Hatoum-Mokdad H, Hughes SJ, Hunt TA, Johnson T, Kavanagh SL, Klinowska TCM, Larner CJB, Lawson M, Lister AS, Longmire D, Marden S, McGuire TM, McMillan C, McMurray L, Morrow CJ, Nissink JWM, Moss TA, O'Donovan DH, Polanski R, Stokes S, Thakur K, Trueman D, Truman C, Tucker MJ, Wang H, Whalley N, Wu D, Wu Y, Yang B, Yang W. Scott JS, et al. Among authors: lawson m. J Med Chem. 2023 Feb 23;66(4):2918-2945. doi: 10.1021/acs.jmedchem.2c01964. Epub 2023 Feb 1. J Med Chem. 2023. PMID: 36727211
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.
Hayhow TG, Williamson B, Lawson M, Cureton N, Braybrooke EL, Campbell A, Carbajo RJ, Cheraghchi-Bashi A, Chiarparin E, Diène CR, Fallan C, Fisher DI, Goldberg FW, Hopcroft L, Hopcroft P, Jackson A, Kettle JG, Klinowska T, Künzel U, Lamont G, Lewis HJ, Maglennon G, Martin S, Gutierrez PM, Morrow CJ, Nikolaou M, Nissink JWM, O'Shea P, Polanski R, Schade M, Scott JS, Smith A, Weber J, Wilson J, Yang B, Crafter C. Hayhow TG, et al. Among authors: lawson m. Commun Biol. 2024 May 13;7(1):563. doi: 10.1038/s42003-024-06238-x. Commun Biol. 2024. PMID: 38740899 Free PMC article.
The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer.
Li Z, Chen F, Chen L, Liu J, Tseng D, Hadi F, Omarjee S, Kishore K, Kent J, Kirkpatrick J, D'Santos C, Lawson M, Gertz J, Sikora MJ, McDonnell DP, Carroll JS, Polyak K, Oesterreich S, Lee AV. Li Z, et al. Among authors: lawson m. NPJ Breast Cancer. 2024 Dec 19;10(1):106. doi: 10.1038/s41523-024-00709-4. NPJ Breast Cancer. 2024. PMID: 39702552 Free PMC article.
EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer.
Li Z, Chen F, Chen L, Liu J, Tseng D, Hadi F, Omarjee S, Kishore K, Kent J, Kirkpatrick J, D'Santos C, Lawson M, Gertz J, Sikora MJ, McDonnell DP, Carroll JS, Polyak K, Oesterreich S, Lee AV. Li Z, et al. Among authors: lawson m. bioRxiv [Preprint]. 2024 Jul 2:2024.06.28.601163. doi: 10.1101/2024.06.28.601163. bioRxiv. 2024. PMID: 39005294 Free PMC article. Preprint.
Gene model for the ortholog of Ilp5 in Drosophila ananassae.
Lawson ME, McAbee M, Lucas RA, Tanner S, Wittke-Thompson J, Pelletier TA, Ozsoy Z, Sterne-Marr R, Rele CP, Reed LK. Lawson ME, et al. MicroPubl Biol. 2024 Dec 8;2024:10.17912/micropub.biology.000782. doi: 10.17912/micropub.biology.000782. eCollection 2024. MicroPubl Biol. 2024. PMID: 39717145 Free PMC article.
Gene model for the ortholog of ImpL2 in Drosophila simulans.
Lawson ME, Jones GM, Runion M, Sims D, Young A, Briggs O, Long LJ, Tin Chi Chak S, Bose I, Rele CP, Reed LK. Lawson ME, et al. MicroPubl Biol. 2024 Nov 30;2024:10.17912/micropub.biology.000715. doi: 10.17912/micropub.biology.000715. eCollection 2024. MicroPubl Biol. 2024. PMID: 39677518 Free PMC article.
The Innate Immune System Surveillance Biomarker p87 in African Americans and Caucasians with Small High-Grade Dysplastic Adenoma [SHiGDA] and Right-Sided JAK3 Colon Mutations May Explain the Presence of Multiple Cancers Revealing an Important Minority of Patients with JAK3 Mutations and Colorectal Neoplasia.
Tobi M, Zhao X, Rodriquez R, Tobi YY, Ganguly T, Kuhn D, McVicker B, Lawson MJ, Lieb J 2nd, Lopes JL. Tobi M, et al. Among authors: lawson mj. Gastrointest Disord (Basel). 2024 Jun 7;6(2):497-512. doi: 10.3390/gidisord6020034. Gastrointest Disord (Basel). 2024. PMID: 39507544 Free PMC article.
An optimized fractionation method reveals insulin-induced membrane surface localization of GLUT1 to increase glycolysis in LβT2 cells.
Molinar-Inglis O, Wiggins K, Varma A, Del Mundo Z, Adame JM, Cozzo A, Muñoz O, Le UV, Trinh D, Garcia AC, Cisneros-Aguirre M, Gonzalez Ramirez ML, Keyes J, Zhang J, Lawson MA, Trejo J, Nicholas DA. Molinar-Inglis O, et al. Among authors: lawson ma. Mol Cell Endocrinol. 2025 Jan 1;595:112405. doi: 10.1016/j.mce.2024.112405. Epub 2024 Oct 29. Mol Cell Endocrinol. 2025. PMID: 39481749 Free article.
Imaging Glucose Metabolism and Dopaminergic Dysfunction in Sheep (Ovis aries) Brain Using Positron Emission Tomography Imaging Reveals Abnormalities in OVT73 Huntington's Disease Sheep.
Williams GK, Akkermans J, Lawson M, Syta P, Staelens S, Adhikari MH, Morton AJ, Nitzsche B, Boltze J, Christou C, Bertoglio D, Ahamed M. Williams GK, et al. Among authors: lawson m. ACS Chem Neurosci. 2024 Nov 6;15(21):4082-4091. doi: 10.1021/acschemneuro.4c00561. Epub 2024 Oct 17. ACS Chem Neurosci. 2024. PMID: 39420554
1,003 results