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Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in the UK Biobank.
Asatryan B, Shah RA, Sharaf Dabbagh G, Landstrom AP, Darbar D, Khanji MY, Lopes LR, van Duijvenboden S, Muser D, Lee AM, Haggerty CM, Arora P, Semsarian C, Reichlin T, Somers VK, Owens AT, Petersen SE, Deo R, Munroe PB, Aung N, Chahal CAA; Genotype-First Approach Investigators. Asatryan B, et al. Among authors: darbar d. JACC Heart Fail. 2024 May;12(5):918-932. doi: 10.1016/j.jchf.2023.07.023. Epub 2023 Sep 13. JACC Heart Fail. 2024. PMID: 37715771 Free article.
Genetics and Pharmacogenetics of Atrial Fibrillation: A Mechanistic Perspective.
Owais A, Barney M, Ly OT, Brown G, Chen H, Sridhar A, Pavel A, Khetani SR, Darbar D. Owais A, et al. Among authors: darbar d. JACC Basic Transl Sci. 2024 Feb 28;9(7):918-934. doi: 10.1016/j.jacbts.2023.12.006. eCollection 2024 Jul. JACC Basic Transl Sci. 2024. PMID: 39170958 Free PMC article. Review.
Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.
Young KL, Fisher V, Deng X, Brody JA, Graff M, Lim E, Lin BM, Xu H, Amin N, An P, Aslibekyan S, Fohner AE, Hidalgo B, Lenzini P, Kraaij R, Medina-Gomez C, Prokić I, Rivadeneira F, Sitlani C, Tao R, van Rooij J, Zhang D, Broome JG, Buth EJ, Heavner BD, Jain D, Smith AV, Barnes K, Boorgula MP, Chavan S, Darbar D, De Andrade M, Guo X, Haessler J, Irvin MR, Kalyani RR, Kardia SLR, Kooperberg C, Kim W, Mathias RA, McDonald ML, Mitchell BD, Peyser PA, Regan EA, Redline S, Reiner AP, Rich SS, Rotter JI, Smith JA, Weiss S, Wiggins KL, Yanek LR, Arnett D, Heard-Costa NL, Leal S, Lin D, McKnight B, Province M, van Duijn CM, North KE, Cupples LA, Liu CT. Young KL, et al. Among authors: darbar d. HGG Adv. 2022 Nov 25;4(1):100163. doi: 10.1016/j.xhgg.2022.100163. eCollection 2023 Jan 12. HGG Adv. 2022. PMID: 36568030 Free PMC article.
Modulation of NOX2 causes obesity-mediated atrial fibrillation.
Sridhar A, DeSantiago J, Chen H, Pavel MA, Ly O, Owais A, Barney M, Jousma J, Nukala SB, Abdelhady K, Massad M, Rizkallah LE, Ong SG, Rehman J, Darbar D. Sridhar A, et al. Among authors: darbar d. J Clin Invest. 2024 Aug 15;134(18):e175447. doi: 10.1172/JCI175447. J Clin Invest. 2024. PMID: 39146015 Free PMC article.
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
Li X, Quick C, Zhou H, Gaynor SM, Liu Y, Chen H, Selvaraj MS, Sun R, Dey R, Arnett DK, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Correa A, Cupples LA, Curran JE, de Vries PS, Duggirala R, Freedman BI, Göring HHH, Guo X, Haessler J, Kalyani RR, Kooperberg C, Kral BG, Lange LA, Manichaikul A, Martin LW, McGarvey ST, Mitchell BD, Montasser ME, Morrison AC, Naseri T, O'Connell JR, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Reupena MS, Rice KM, Rich SS, Sitlani CM, Smith JA, Taylor KD, Vasan RS, Willer CJ, Wilson JG, Yanek LR, Zhao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group; Rotter JI, Natarajan P, Peloso GM, Li Z, Lin X. Li X, et al. Nat Genet. 2023 Jan;55(1):154-164. doi: 10.1038/s41588-022-01225-6. Epub 2022 Dec 23. Nat Genet. 2023. PMID: 36564505 Free PMC article.
Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility.
Jiang X, Ly OT, Chen H, Zhang Z, Ibarra BA, Pavel MA, Brown GE, Sridhar A, Tofovic D, Swick A, Marszalek R, Vanoye CG, Navales F, George AL Jr, Khetani SR, Rehman J, Gao Y, Darbar D, Saxena A. Jiang X, et al. Among authors: darbar d. iScience. 2024 Jun 27;27(7):110395. doi: 10.1016/j.isci.2024.110395. eCollection 2024 Jul 19. iScience. 2024. PMID: 39100923 Free PMC article.
261 results