Ambudkar SV - Search Results

1

Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters.

Sajid A, Rahman H, Ambudkar SV. Sajid A, et al. Among authors: ambudkar sv. Nat Rev Cancer. 2023 Nov;23(11):762-779. doi: 10.1038/s41568-023-00612-3. Epub 2023 Sep 15. Nat Rev Cancer. 2023. PMID: 37714963 Review.

2

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).

Sajid A, Lusvarghi S, Chufan EE, Ambudkar SV. Sajid A, et al. Among authors: ambudkar sv. PLoS One. 2018 Sep 28;13(9):e0204693. doi: 10.1371/journal.pone.0204693. eCollection 2018. PLoS One. 2018. PMID: 30265721 Free PMC article.

3

An A666G mutation in transmembrane helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites.

Arya N, Rahman H, Rudrow A, Wagner M, Schmitt L, Ambudkar SV, Golin J. Arya N, et al. Among authors: ambudkar sv. Mol Microbiol. 2019 Oct;112(4):1131-1144. doi: 10.1111/mmi.14351. Epub 2019 Jul 23. Mol Microbiol. 2019. PMID: 31294884 Free PMC article.

4

Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1).

Sajid A, Raju N, Lusvarghi S, Vahedi S, Swenson RE, Ambudkar SV. Sajid A, et al. Among authors: ambudkar sv. Drug Metab Dispos. 2019 Oct;47(10):1013-1023. doi: 10.1124/dmd.119.087734. Epub 2019 Aug 1. Drug Metab Dispos. 2019. PMID: 31371421 Free PMC article.

5

Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element.

Rahman H, Rudrow A, Carneglia J, Joly SSP, Nicotera D, Naldrett M, Choy J, Ambudkar SV, Golin J. Rahman H, et al. Among authors: ambudkar sv. G3 (Bethesda). 2020 Jan 7;10(1):357-369. doi: 10.1534/g3.119.400863. G3 (Bethesda). 2020. PMID: 31757931 Free PMC article.

6

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein.

Sajid A, Lusvarghi S, Murakami M, Chufan EE, Abel B, Gottesman MM, Durell SR, Ambudkar SV. Sajid A, et al. Among authors: ambudkar sv. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29609-29617. doi: 10.1073/pnas.2016270117. Epub 2020 Nov 9. Proc Natl Acad Sci U S A. 2020. PMID: 33168729 Free PMC article.

7

Residues forming the gating regions of asymmetric multidrug transporter Pdr5 also play roles in conformational switching and protein folding.

Alhumaidi M, Nentwig LM, Rahman H, Schmitt L, Rudrow A, Harris A, Dillon C, Restrepo L, Lamping E, Arya N, Ambudkar SV, Choy JS, Golin J. Alhumaidi M, et al. Among authors: ambudkar sv. J Biol Chem. 2022 Dec;298(12):102689. doi: 10.1016/j.jbc.2022.102689. Epub 2022 Nov 10. J Biol Chem. 2022. PMID: 36370844 Free PMC article.

8

Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport.

Rahman H, Ware MJ, Sajid A, Lusvarghi S, Durell SR, Ambudkar SV. Rahman H, et al. Among authors: ambudkar sv. Cancers (Basel). 2023 Jul 1;15(13):3459. doi: 10.3390/cancers15133459. Cancers (Basel). 2023. PMID: 37444569 Free PMC article.

9

Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer.

Bharathiraja P, Yadav P, Sajid A, Ambudkar SV, Prasad NR. Bharathiraja P, et al. Among authors: ambudkar sv. Drug Resist Updat. 2023 Nov;71:101004. doi: 10.1016/j.drup.2023.101004. Epub 2023 Aug 21. Drug Resist Updat. 2023. PMID: 37660590 Free PMC article. Review.

10

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier.

Thomas JR, Frye WJE, Robey RW, Warner AC, Butcher D, Matta JL, Morgan TC, Edmondson EF, Salazar PB, Ambudkar SV, Gottesman MM. Thomas JR, et al. Among authors: ambudkar sv. Fluids Barriers CNS. 2024 Mar 15;21(1):27. doi: 10.1186/s12987-024-00529-5. Fluids Barriers CNS. 2024. PMID: 38491505 Free PMC article.

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