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214 results

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Page 1
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.
Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. Blaeschke F, et al. Among authors: to a. Cell. 2023 Sep 14;186(19):4216-4234.e33. doi: 10.1016/j.cell.2023.08.013. Cell. 2023. PMID: 37714135 Free PMC article.
ModPoKI's modularity allowed us to generate an 10,000-member library of TF combinations. Non-viral KI of a combined BATF-TFAP4 polycistronic construct enhanced fitness. Overexpressed BATF and TFAP4 co-occupy and regulate key gene targets to reprogram T cell f …
ModPoKI's modularity allowed us to generate an 10,000-member library of TF combinations. Non-viral KI of a combined BATF-TFAP4 …
An evolved AAV variant enables efficient genetic engineering of murine T cells.
Nyberg WA, Ark J, To A, Clouden S, Reeder G, Muldoon JJ, Chung JY, Xie WH, Allain V, Steinhart Z, Chang C, Talbot A, Kim S, Rosales A, Havlik LP, Pimentel H, Asokan A, Eyquem J. Nyberg WA, et al. Among authors: to a. Cell. 2023 Jan 19;186(2):446-460.e19. doi: 10.1016/j.cell.2022.12.022. Epub 2023 Jan 12. Cell. 2023. PMID: 36638795 Free PMC article.
Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin efficiencies, but the tropism of current AAV serotypes restricts their use to human T cells employed in immunodeficient mouse models. To enable targeted knockins in murine T cell …
Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin efficiencies, but the tropism of current AAV serotyp …
Targeting monoamine oxidase A for T cell-based cancer immunotherapy.
Wang X, Li B, Kim YJ, Wang YC, Li Z, Yu J, Zeng S, Ma X, Choi IY, Di Biase S, Smith DJ, Zhou Y, Li YR, Ma F, Huang J, Clarke N, To A, Gong L, Pham AT, Moon H, Pellegrini M, Yang L. Wang X, et al. Among authors: to a. Sci Immunol. 2021 May 14;6(59):eabh2383. doi: 10.1126/sciimmunol.abh2383. Sci Immunol. 2021. PMID: 33990379
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Wang YC, Wang X, Yu J, Ma F, Li Z, Zhou Y, Zeng S, Ma X, Li YR, Neal A, Huang J, To A, Clarke N, Memarzadeh S, Pellegrini M, Yang L. Wang YC, et al. Among authors: to a. Nat Commun. 2021 Jun 10;12(1):3530. doi: 10.1038/s41467-021-23164-2. Nat Commun. 2021. PMID: 34112755 Free PMC article.
Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment and improve cancer immunotherapy. ...Together, these data identify MAO-A as a critical regulator of TAMs and support repurposin …
Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment a …
Creatine uptake regulates CD8 T cell antitumor immunity.
Di Biase S, Ma X, Wang X, Yu J, Wang YC, Smith DJ, Zhou Y, Li Z, Kim YJ, Clarke N, To A, Yang L. Di Biase S, et al. Among authors: to a. J Exp Med. 2019 Dec 2;216(12):2869-2882. doi: 10.1084/jem.20182044. Epub 2019 Oct 18. J Exp Med. 2019. PMID: 31628186 Free PMC article.
T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of th …
T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just beg …
Recent advancement in the spatial immuno-oncology.
To A, Yu Z, Sugimura R. To A, et al. Semin Cell Dev Biol. 2025 Feb;166:22-28. doi: 10.1016/j.semcdb.2024.12.003. Epub 2024 Dec 19. Semin Cell Dev Biol. 2025. PMID: 39705969 Review.
Synthesis and Application of D- and 13C-Labelled tert-Butyl Hoechst Dye.
Vlasenko YA, To AJ, Fortier T, Evans NM, Lindsay CJ, Palermo PJ, Dieckmann T, Murphy GK. Vlasenko YA, et al. Among authors: to aj. J Labelled Comp Radiopharm. 2024 Oct-Nov;67(12-13):425-430. doi: 10.1002/jlcr.4123. Epub 2024 Oct 23. J Labelled Comp Radiopharm. 2024. PMID: 39441744
A Serological Multiplexed Immunoassay (MIA) Detects Antibody Reactivity to SARS-CoV-2 and Other Viral Pathogens in Liberia and Is Configurable as a Multiplexed Inhibition Test (MINT).
Haun BK, To A, Williams CA, Ball A, Fong K, Wong TAS, Shobayo B, Teahton J, Ching L, Kamara V, Tekah DM, Humphrey P, Berestecky J, Nerurkar VR, Lehrer AT. Haun BK, et al. Among authors: to a. Immuno. 2024 Mar;4(1):108-124. doi: 10.3390/immuno4010007. Epub 2024 Mar 3. Immuno. 2024. PMID: 39391865 Free PMC article.
214 results