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204 results

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Page 1
shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.
Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. Deng T, et al. Among authors: uehling d. Cancer Res. 2014 Apr 1;74(7):2119-30. doi: 10.1158/0008-5472.CAN-13-2138. Epub 2014 Jan 31. Cancer Res. 2014. PMID: 24487029
Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.
Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR. Grinshtein N, et al. Among authors: uehling d. Oncotarget. 2016 Sep 13;7(37):59360-59376. doi: 10.18632/oncotarget.10661. Oncotarget. 2016. PMID: 27449082 Free PMC article.
The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.
Edilova MI, Law JC, Zangiabadi S, Ting K, Mbanwi AN, Arruda A, Uehling D, Isaac M, Prakesch M, Al-Awar R, Minden MD, Abdul-Sater AA, Watts TH. Edilova MI, et al. Among authors: uehling d. Oncoimmunology. 2021 Sep 23;10(1):1943234. doi: 10.1080/2162402X.2021.1943234. eCollection 2021. Oncoimmunology. 2021. PMID: 34589290 Free PMC article.
Small molecules reveal an alternative mechanism of Bax activation.
Brahmbhatt H, Uehling D, Al-Awar R, Leber B, Andrews D. Brahmbhatt H, et al. Among authors: uehling d. Biochem J. 2016 Apr 15;473(8):1073-83. doi: 10.1042/BCJ20160118. Epub 2016 Feb 25. Biochem J. 2016. PMID: 26916338 Free PMC article.
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
Zhang Q, Xiao K, Paredes JM, Mamonova T, Sneddon WB, Liu H, Wang D, Li S, McGarvey JC, Uehling D, Al-Awar R, Joseph B, Jean-Alphonse F, Orte A, Friedman PA. Zhang Q, et al. Among authors: uehling d. J Biol Chem. 2019 Mar 22;294(12):4546-4571. doi: 10.1074/jbc.RA119.007421. Epub 2019 Jan 29. J Biol Chem. 2019. PMID: 30696771 Free PMC article.
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.
Uehling DE, Joseph B, Chung KC, Zhang AX, Ler S, Prakesch MA, Poda G, Grouleff J, Aman A, Kiyota T, Leung-Hagesteijn C, Konda JD, Marcellus R, Griffin C, Subramaniam R, Abibi A, Strathdee CA, Isaac MB, Al-Awar R, Tiedemann RE. Uehling DE, et al. J Med Chem. 2021 Aug 12;64(15):11129-11147. doi: 10.1021/acs.jmedchem.1c00506. Epub 2021 Jul 22. J Med Chem. 2021. PMID: 34291633
Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.
Liang Y, Jeganathan S, Marastoni S, Sharp A, Figueiredo I, Marcellus R, Mawson A, Shalev Z, Pesic A, Sweet J, Guo H, Uehling D, Gurel B, Neeb A, He HH, Montgomery B, Koritzinsky M, Oakes S, de Bono JS, Gleave M, Zoubeidi A, Wouters BG, Joshua AM. Liang Y, et al. Among authors: uehling d. Clin Cancer Res. 2021 Apr 15;27(8):2340-2351. doi: 10.1158/1078-0432.CCR-20-3260. Epub 2021 Feb 4. Clin Cancer Res. 2021. PMID: 33542074
204 results