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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings.
Meira M, Frey A, Chekkat N, Rybczynska M, Sellam Z, Park JS, Gazzaniga FS, Parmentier A, Le Gall M, Freeman GJ, Kasper DL, Sharpe AH, Rambeaux E, Shamshiev A. Meira M, et al. Among authors: kasper dl. MAbs. 2024 Jan-Dec;16(1):2432403. doi: 10.1080/19420862.2024.2432403. Epub 2024 Nov 26. MAbs. 2024. PMID: 39588913 Free PMC article.
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions.
Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S. Cong J, et al. Among authors: kasper dl. Immunity. 2024 Apr 9;57(4):876-889.e11. doi: 10.1016/j.immuni.2024.02.014. Epub 2024 Mar 12. Immunity. 2024. PMID: 38479384
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.
Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed J, Ringel A, Barends J, Wu C, Balskus E, Thiagarajah J, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper SB. Bao B, et al. Among authors: kasper dl. Cell Mol Gastroenterol Hepatol. 2024;18(2):101350. doi: 10.1016/j.jcmgh.2024.04.007. Epub 2024 May 3. Cell Mol Gastroenterol Hepatol. 2024. PMID: 38704148 Free PMC article.
Gut complement induced by the microbiota combats pathogens and spares commensals.
Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, Yang D, Liu R, Macbeth JC, Do EA, Andrade WA, Yang T, Cho HS, Gazzaniga FS, Ilves M, Coronado D, Thompson C, Hang S, Chiu IM, Moffitt JR, Hsiao A, Mekalanos JJ, Benoist C, Kasper DL. Wu M, et al. Among authors: kasper dl. Cell. 2024 Feb 15;187(4):897-913.e18. doi: 10.1016/j.cell.2023.12.036. Epub 2024 Jan 26. Cell. 2024. PMID: 38280374
Gut microbial fatty acid isomerization modulates intraepithelial T cells.
Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W, Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF, Kasper DL. Song X, et al. Among authors: kasper dl. Nature. 2023 Jul;619(7971):837-843. doi: 10.1038/s41586-023-06265-4. Epub 2023 Jun 28. Nature. 2023. PMID: 37380774
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance.
Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Park JS, et al. Among authors: kasper dl. Nature. 2023 May;617(7960):377-385. doi: 10.1038/s41586-023-06026-3. Epub 2023 May 3. Nature. 2023. PMID: 37138075 Free PMC article.
351 results