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Scalable GMP-compliant gene correction of CD4+ T cells with IDLV template functionally validated in vitro and in vivo.
Asperti C, Canarutto D, Porcellini S, Sanvito F, Cecere F, Vavassori V, Ferrari S, Rovelli E, Albano L, Jacob A, Sergi Sergi L, Montaldo E, Ferrua F, González-Granado LI, Lougaris V, Badolato R, Finocchi A, Villa A, Radrizzani M, Naldini L. Asperti C, et al. Among authors: naldini l. Mol Ther Methods Clin Dev. 2023 Aug 23;30:546-557. doi: 10.1016/j.omtm.2023.08.020. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37693944 Free PMC article.
A step toward stem cell engineering in vivo.
Ferrari S, Naldini L. Ferrari S, et al. Among authors: naldini l. Science. 2023 Jul 28;381(6656):378-379. doi: 10.1126/science.adj0997. Epub 2023 Jul 27. Science. 2023. PMID: 37499013
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases.
Kerzel T, Giacca G, Beretta S, Bresesti C, Notaro M, Scotti GM, Balestrieri C, Canu T, Redegalli M, Pedica F, Genua M, Ostuni R, Kajaste-Rudnitski A, Oshima M, Tonon G, Merelli I, Aldrighetti L, Dellabona P, Coltella N, Doglioni C, Rancoita PMV, Sanvito F, Naldini L, Squadrito ML. Kerzel T, et al. Among authors: naldini l. Cancer Cell. 2023 Nov 13;41(11):1892-1910.e10. doi: 10.1016/j.ccell.2023.09.014. Epub 2023 Oct 19. Cancer Cell. 2023. PMID: 37863068 Free article.
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells.
Cianciotti BC, Magnani ZI, Ugolini A, Camisa B, Merelli I, Vavassori V, Potenza A, Imparato A, Manfredi F, Abbati D, Perani L, Spinelli A, Shifrut E, Ciceri F, Vago L, Di Micco R, Naldini L, Genovese P, Ruggiero E, Bonini C. Cianciotti BC, et al. Among authors: naldini l. Front Immunol. 2024 Feb 29;15:1315283. doi: 10.3389/fimmu.2024.1315283. eCollection 2024. Front Immunol. 2024. PMID: 38510235 Free PMC article.
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells.
Della Volpe L, Midena F, Vacca R, Tavella T, Alessandrini L, Farina G, Brandas C, Lo Furno E, Giannetti K, Carsana E, Naldini MM, Barcella M, Ferrari S, Beretta S, Santoro A, Porcellini S, Varesi A, Gilioli D, Conti A, Merelli I, Gentner B, Villa A, Naldini L, Di Micco R. Della Volpe L, et al. Among authors: naldini l. Cell Rep Med. 2024 Nov 19;5(11):101823. doi: 10.1016/j.xcrm.2024.101823. Epub 2024 Nov 12. Cell Rep Med. 2024. PMID: 39536752 Free PMC article.
313 results