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Page 1
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β.
Hommel U, Hurth K, Rondeau JM, Vulpetti A, Ostermeier D, Boettcher A, Brady JP, Hediger M, Lehmann S, Koch E, Blechschmidt A, Yamamoto R, Tundo Dottorello V, Haenni-Holzinger S, Kaiser C, Lehr P, Lingel A, Mureddu L, Schleberger C, Blank J, Ramage P, Freuler F, Eder J, Bornancin F. Hommel U, et al. Among authors: koch e. Nat Commun. 2023 Sep 7;14(1):5497. doi: 10.1038/s41467-023-41190-0. Nat Commun. 2023. PMID: 37679328 Free PMC article.
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Morvan F, Rondeau JM, Zou C, Minetti G, Scheufler C, Scharenberg M, Jacobi C, Brebbia P, Ritter V, Toussaint G, Koelbing C, Leber X, Schilb A, Witte F, Lehmann S, Koch E, Geisse S, Glass DJ, Lach-Trifilieff E. Morvan F, et al. Among authors: koch e. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12448-12453. doi: 10.1073/pnas.1707925114. Epub 2017 Nov 6. Proc Natl Acad Sci U S A. 2017. PMID: 29109273 Free PMC article.
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches.
Vulpetti A, Rondeau JM, Bellance MH, Blank J, Boesch R, Boettcher A, Bornancin F, Buhr S, Connor LE, Dumelin CE, Esser O, Hediger M, Hintermann S, Hommel U, Koch E, Lapointe G, Leder L, Lehmann S, Lehr P, Meier P, Muller L, Ostermeier D, Ramage P, Schiebel-Haddad S, Smith AB, Stojanovic A, Velcicky J, Yamamoto R, Hurth K. Vulpetti A, et al. Among authors: koch e. J Med Chem. 2024 May 23;67(10):8141-8160. doi: 10.1021/acs.jmedchem.4c00240. Epub 2024 May 10. J Med Chem. 2024. PMID: 38728572
Genomics yields biological and phenotypic insights into bipolar disorder.
O'Connell KS, Koromina M, van der Veen T, Boltz T, David FS, Yang JMK, Lin KH, Wang X, Coleman JRI, Mitchell BL, McGrouther CC, Rangan AV, Lind PA, Koch E, Harder A, Parker N, Bendl J, Adorjan K, Agerbo E, Albani D, Alemany S, Alliey-Rodriguez N, Als TD, Andlauer TFM, Antoniou A, Ask H, Bass N, Bauer M, Beins EC, Bigdeli TB, Pedersen CB, Boks MP, Børte S, Bosch R, Brum M, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Bybjerg-Grauholm J, Byerley W, Cabana-Domínguez J, Cairns MJ, Carpiniello B, Casas M, Cervantes P, Chatzinakos C, Chen HC, Clarence T, Clarke TK, Claus I, Coombes B, Corfield EC, Cruceanu C, Cuellar-Barboza A, Czerski PM, Dafnas K, Dale AM, Dalkner N, Degenhardt F, DePaulo JR, Djurovic S, Drange OK, Escott-Price V, Fanous AH, Fellendorf FT, Ferrier IN, Forty L, Frank J, Frei O, Freimer NB, Fullard JF, Garnham J, Gizer IR, Gordon SD, Gordon-Smith K, Greenwood TA, Grove J, Guzman-Parra J, Ha TH, Hahn T, Haraldsson M, Hautzinger M, Havdahl A, Heilbronner U, Hellgren D, Herms S, Hickie IB, Hoffmann P, Holmans PA, Huang MC, Ikeda M, Jamain S, Johnson JS, Jonsson L, Kalman JL, Kamatani Y, Kennedy JL, Kim E, Kim J, Kittel-Schneider S, Knowles JA, Kogevinas M, Kranz TM, K… See abstract for full author list ➔ O'Connell KS, et al. Among authors: koch e. Nature. 2025 Jan 22. doi: 10.1038/s41586-024-08468-9. Online ahead of print. Nature. 2025. PMID: 39843750
Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs.
Koch E, Jürgenson T, Einarsson G, Mitchell B, Harder A, García-Marín LM, Krebs K, Lin Y, Shadrin A, Xiong Y, Frei O, Lu Y, Hägg S, Renteria M, Medland S, Wray N, Martin N, Hübel C, Breen G, Thorgeirsson T, Stefansson H, Stefansson K, Lehto K, Milani L, Andreassen O, O Connell K. Koch E, et al. Res Sq [Preprint]. 2024 Dec 23:rs.3.rs-5418279. doi: 10.21203/rs.3.rs-5418279/v1. Res Sq. 2024. PMID: 39764137 Free PMC article. Preprint.
Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.
Jaholkowski P, Bahrami S, Fominykh V, Hindley GFL, Tesfaye M, Parekh P, Parker N, Filiz TT, Nordengen K, Hagen E, Koch E, Bakken NR, Frei E, Birkenæs V, Rahman Z, Frei O, Haavik J, Djurovic S, Dale AM, Smeland OB, O'Connell KS, Shadrin AA, Andreassen OA. Jaholkowski P, et al. Among authors: koch e. Neurobiol Dis. 2024 Dec;203:106750. doi: 10.1016/j.nbd.2024.106750. Epub 2024 Nov 27. Neurobiol Dis. 2024. PMID: 39608471 Free article.
918 results