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Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine.
Quixabeira DCA, Jirovec E, Pakola S, Havunen R, Basnet S, Santos JM, Kudling TV, Clubb JHA, Haybout L, Arias V, Grönberg-Vähä-Koskela S, Cervera-Carrascon V, Pasanen A, Anttila M, Tapper J, Kanerva A, Hemminki A. Quixabeira DCA, et al. Among authors: cervera carrascon v. Cancer Gene Ther. 2023 Nov;30(11):1543-1553. doi: 10.1038/s41417-023-00658-3. Epub 2023 Sep 4. Cancer Gene Ther. 2023. PMID: 37666898 Free PMC article.
Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes.
Zafar S, Quixabeira DCA, Kudling TV, Cervera-Carrascon V, Santos JM, Grönberg-Vähä-Koskela S, Zhao F, Aronen P, Heiniö C, Havunen R, Sorsa S, Kanerva A, Hemminki A. Zafar S, et al. Cancer Gene Ther. 2021 May;28(5):442-454. doi: 10.1038/s41417-020-00226-z. Epub 2020 Sep 12. Cancer Gene Ther. 2021. PMID: 32920593 Free PMC article.
Oncolytic Adenovirus Type 3 Coding for CD40L Facilitates Dendritic Cell Therapy of Prostate Cancer in Humanized Mice and Patient Samples.
Zafar S, Basnet S, Launonen IM, Quixabeira DCA, Santos J, Hemminki O, Malmstedt M, Cervera-Carrascon V, Aronen P, Kalliokoski R, Havunen R, Rannikko A, Mirtti T, Matikainen M, Kanerva A, Hemminki A. Zafar S, et al. Hum Gene Ther. 2021 Feb;32(3-4):192-202. doi: 10.1089/hum.2020.222. Epub 2021 Jan 22. Hum Gene Ther. 2021. PMID: 33050725 Free PMC article.
Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression.
Kudling TV, Clubb JHA, Quixabeira DCA, Santos JM, Havunen R, Kononov A, Heiniö C, Cervera-Carrascon V, Pakola S, Basnet S, Grönberg-Vähä-Koskela S, Arias V, Gladwyn-Ng I, Aro K, Bäck L, Räsänen J, Ilonen I, Borenius K, Räsänen M, Hemminki O, Rannikko A, Kanerva A, Tapper J, Hemminki A. Kudling TV, et al. Oncoimmunology. 2022 Jul 12;11(1):2096572. doi: 10.1080/2162402X.2022.2096572. eCollection 2022. Oncoimmunology. 2022. PMID: 35845722 Free PMC article.
Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors.
Basnet S, Santos JM, Quixabeira DCA, Clubb JHA, Grönberg-Vähä-Koskela SAM, Arias V, Pakola S, Kudling TV, Heiniö C, Havunen R, Cervera-Carrascon V, Sorsa S, Anttila M, Kanerva A, Hemminki A. Basnet S, et al. Mol Ther Oncolytics. 2022 Dec 28;28:59-73. doi: 10.1016/j.omto.2022.12.007. eCollection 2023 Mar 16. Mol Ther Oncolytics. 2022. PMID: 36699617 Free PMC article.
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