Sansom MSP - Search Results

1

The energetics and ion coupling of cholesterol transport through Patched1.

Ansell TB, Corey RA, Viti LV, Kinnebrew M, Rohatgi R, Siebold C, Sansom MSP. Ansell TB, et al. Among authors: sansom msp. Sci Adv. 2023 Aug 25;9(34):eadh1609. doi: 10.1126/sciadv.adh1609. Epub 2023 Aug 23. Sci Adv. 2023. PMID: 37611095 Free PMC article.

2

Structural basis of Smoothened regulation by its extracellular domains.

Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C. Byrne EFX, et al. Among authors: sansom msp. Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20. Nature. 2016. PMID: 27437577 Free PMC article.

3

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP. Hedger G, et al. Among authors: sansom msp. Structure. 2019 Mar 5;27(3):549-559.e2. doi: 10.1016/j.str.2018.11.003. Epub 2018 Dec 27. Structure. 2019. PMID: 30595453 Free PMC article.

4

A lipid gating mechanism for the channel-forming O antigen ABC transporter.

Caffalette CA, Corey RA, Sansom MSP, Stansfeld PJ, Zimmer J. Caffalette CA, et al. Among authors: sansom msp. Nat Commun. 2019 Feb 18;10(1):824. doi: 10.1038/s41467-019-08646-8. Nat Commun. 2019. PMID: 30778065 Free PMC article.

5

Insights into Membrane Protein-Lipid Interactions from Free Energy Calculations.

Corey RA, Vickery ON, Sansom MSP, Stansfeld PJ. Corey RA, et al. Among authors: sansom msp. J Chem Theory Comput. 2019 Oct 8;15(10):5727-5736. doi: 10.1021/acs.jctc.9b00548. Epub 2019 Sep 17. J Chem Theory Comput. 2019. PMID: 31476127 Free PMC article.

6

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Rudolf AF, et al. Among authors: sansom msp. Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548691 Free PMC article.

7

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.

Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP. Wang Q, et al. Among authors: sansom msp. Structure. 2020 Feb 4;28(2):169-184.e5. doi: 10.1016/j.str.2019.11.005. Epub 2019 Dec 2. Structure. 2020. PMID: 31806353 Free PMC article.

8

The energetics of protein-lipid interactions as viewed by molecular simulations.

Corey RA, Stansfeld PJ, Sansom MSP. Corey RA, et al. Among authors: sansom msp. Biochem Soc Trans. 2020 Feb 28;48(1):25-37. doi: 10.1042/BST20190149. Biochem Soc Trans. 2020. PMID: 31872229 Free PMC article. Review.

9

Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels.

Duncan AL, Corey RA, Sansom MSP. Duncan AL, et al. Among authors: sansom msp. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7803-7813. doi: 10.1073/pnas.1918387117. Epub 2020 Mar 25. Proc Natl Acad Sci U S A. 2020. PMID: 32213593 Free PMC article.

10

The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor.

Ansell TB, Song W, Sansom MSP. Ansell TB, et al. Among authors: sansom msp. Biophys J. 2020 Jul 21;119(2):300-313. doi: 10.1016/j.bpj.2020.06.009. Epub 2020 Jun 17. Biophys J. 2020. PMID: 32610088 Free PMC article.

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