Lai M - Search Results

1

Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Among authors: lai m. Mol Cancer. 2023 Aug 19;22(1):139. doi: 10.1186/s12943-023-01842-7. Mol Cancer. 2023. PMID: 37598189 Free PMC article. No abstract available.

2

Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors.

Diao Y, Fang X, Song P, Lai M, Tong L, Hao Y, Dou D, Liu Y, Ding J, Zhao Z, Xie H, Li H. Diao Y, et al. Among authors: lai m. Bioorg Med Chem. 2019 Aug 1;27(15):3390-3395. doi: 10.1016/j.bmc.2019.06.023. Epub 2019 Jun 12. Bioorg Med Chem. 2019. PMID: 31221612

3

Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR^{L858R/T790M/C797S}).

Shen J, Zhang T, Zhu SJ, Sun M, Tong L, Lai M, Zhang R, Xu W, Wu R, Ding J, Yun CH, Xie H, Lu X, Ding K. Shen J, et al. Among authors: lai m. J Med Chem. 2019 Aug 8;62(15):7302-7308. doi: 10.1021/acs.jmedchem.9b00576. Epub 2019 Jul 23. J Med Chem. 2019. PMID: 31298540

4

Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors.

Lai MZ, Song PR, Dou D, Diao YY, Tong LJ, Zhang T, Xie H, Li HL, Ding J. Lai MZ, et al. Acta Pharmacol Sin. 2020 Mar;41(3):415-422. doi: 10.1038/s41401-019-0250-8. Epub 2019 Jul 17. Acta Pharmacol Sin. 2020. PMID: 31316181 Free PMC article.

5

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Among authors: lai m. Mol Cancer. 2020 May 13;19(1):90. doi: 10.1186/s12943-020-01202-9. Mol Cancer. 2020. PMID: 32404161 Free PMC article.

6

Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation.

Su Z, Yang T, Wang J, Lai M, Tong L, Wumaier G, Chen Z, Li S, Li H, Xie H, Zhao Z. Su Z, et al. Among authors: lai m. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127327. doi: 10.1016/j.bmcl.2020.127327. Epub 2020 Jun 9. Bioorg Med Chem Lett. 2020. PMID: 32631532

7

Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS^G12C inhibitors.

Xiao X, Lai M, Song Z, Geng M, Ding J, Xie H, Zhang A. Xiao X, et al. Among authors: lai m. Eur J Med Chem. 2021 Mar 5;213:113082. doi: 10.1016/j.ejmech.2020.113082. Epub 2020 Dec 4. Eur J Med Chem. 2021. PMID: 33309163

8

Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Among authors: lai m. Mol Cancer. 2021 Aug 17;20(1):102. doi: 10.1186/s12943-021-01391-x. Mol Cancer. 2021. PMID: 34404402 Free PMC article. No abstract available.

9

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.

Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Liu Y, et al. Among authors: lai m. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. Cancer Sci. 2022. PMID: 34855271 Free PMC article.

10

Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR^T790M/C797S Mutants.

Li S, Zhang T, Zhu SJ, Lei C, Lai M, Peng L, Tong L, Pang Z, Lu X, Ding J, Ren X, Yun CH, Xie H, Ding K. Li S, et al. Among authors: lai m. ACS Med Chem Lett. 2022 Jan 7;13(2):196-202. doi: 10.1021/acsmedchemlett.1c00555. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35178175 Free PMC article.

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