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CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic.
van Dinther M, Cunningham KT, Singh SP, White MPJ, Campion T, Ciancia C, van Veelen PA, de Ru AH, González-Prieto R, Mukundan A, Byeon CH, Staggers SR, Hinck CS, Hinck AP, Dijke PT, Maizels RM. van Dinther M, et al. Among authors: mukundan a. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2302370120. doi: 10.1073/pnas.2302370120. Epub 2023 Aug 17. Proc Natl Acad Sci U S A. 2023. PMID: 37590410 Free PMC article.
The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells.
Singh SP, Smyth DJ, Cunningham K, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wosowska N, Sanders A, Jin R, Lilla S, Zanivan S, Schoenherr C, Inman G, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: mukundan a. bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566701. doi: 10.1101/2023.11.13.566701. bioRxiv. 2023. PMID: 38014296 Free PMC article. Preprint.
TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts.
White SE, Schwartze TA, Mukundan A, Schoenherr C, Singh SP, van Dinther M, Cunningham KT, White MPJ, Campion T, Pritchard J, Hinck CS, Ten Dijke P, Inman G, Maizels RM, Hinck AP. White SE, et al. Among authors: mukundan a. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573140. doi: 10.1101/2023.12.22.573140. bioRxiv. 2023. PMID: 38187573 Free PMC article. Preprint.
The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding.
Singh SP, Smyth DJ, Cunningham KT, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wąsowska N, Sanders A, Jin R, White RF, Lilla S, Zanivan S, Schoenherr C, Inman GJ, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: mukundan a. EMBO Rep. 2024 Nov 28. doi: 10.1038/s44319-024-00323-2. Online ahead of print. EMBO Rep. 2024. PMID: 39609640 Free article.
Hydra 2022: return of the interactive conference on helminth parasitology after the pandemic.
McManus CM, Bouchery T, Suleiman M, Kildemoes AO, Ferguson A, Wang T, Finlay CM, Chan R, Renahan T, Mukundan A, Nkurunungi G, Bobardt SD. McManus CM, et al. Among authors: mukundan a. Trends Parasitol. 2022 Dec;38(12):999-1007. doi: 10.1016/j.pt.2022.09.013. Epub 2022 Nov 2. Trends Parasitol. 2022. PMID: 36335007 No abstract available.
RNA diagnostics and therapeutics: a comprehensive review.
Saju AF, Mukundan A, Divyashree Ms, Chandrashekhar R, Mahadev Rao A. Saju AF, et al. Among authors: mukundan a. RNA Biol. 2025 Dec;22(1):1-11. doi: 10.1080/15476286.2024.2449277. Epub 2025 Jan 3. RNA Biol. 2025. PMID: 39744758 Free article. Review.
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