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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Chiem K, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, De Jonghe S, Narayanan A, Einav S. Saul S, et al. Among authors: khalil am. J Clin Invest. 2023 Oct 2;133(19):e169510. doi: 10.1172/JCI169510. J Clin Invest. 2023. PMID: 37581931 Free PMC article.
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody.
Piepenbrink MS, Park JG, Deshpande A, Loos A, Ye C, Basu M, Sarkar S, Khalil AM, Chauvin D, Woo J, Lovalenti P, Erdmann NB, Goepfert PA, Truong VL, Bowen RA, Walter MR, Martinez-Sobrido L, Kobie JJ. Piepenbrink MS, et al. Among authors: khalil am. PLoS Pathog. 2022 Jul 21;18(7):e1010691. doi: 10.1371/journal.ppat.1010691. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35862475 Free PMC article.
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses.
Silva RP, Huang Y, Nguyen AW, Hsieh CL, Olaluwoye OS, Kaoud TS, Wilen RE, Qerqez AN, Park JG, Khalil AM, Azouz LR, Le KC, Bohanon AL, DiVenere AM, Liu Y, Lee AG, Amengor DA, Shoemaker SR, Costello SM, Padlan EA, Marqusee S, Martinez-Sobrido L, Dalby KN, D'Arcy S, McLellan JS, Maynard JA. Silva RP, et al. Among authors: khalil am. Elife. 2023 Mar 21;12:e83710. doi: 10.7554/eLife.83710. Elife. 2023. PMID: 36942851 Free PMC article.
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein.
Abu-Shmais AA, Guo L, Khalil AM, Miller RJ, Janke AK, Vukovich MJ, Bass LE, Suresh YP, Rush SA, Wolters RM, Kose N, Carnahan RH, Crowe JE Jr, Bonami RH, Mousa JJ, McLellan JS, Georgiev IS. Abu-Shmais AA, et al. Among authors: khalil am. bioRxiv [Preprint]. 2024 Nov 1:2024.10.31.621295. doi: 10.1101/2024.10.31.621295. bioRxiv. 2024. PMID: 39554078 Free PMC article. Preprint.
Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants.
Piepenbrink MS, Khalil AM, Chang A, Mostafa A, Basu M, Sarkar S, Panjwani S, Ha YH, Ma Y, Ye C, Wang Q, Green TJ, Kizziah JL, Erdmann NB, Goepfert PA, Liu L, Ho DD, Martinez-Sobrido L, Walter MR, Kobie JJ. Piepenbrink MS, et al. Among authors: khalil am. Npj Viruses. 2024;2(1):55. doi: 10.1038/s44298-024-00063-z. Epub 2024 Nov 14. Npj Viruses. 2024. PMID: 39553825 Free PMC article.
273 results