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A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.
Dickson AS, Pauzaite T, Arnaiz E, Ortmann BM, West JA, Volkmar N, Martinelli AW, Li Z, Wit N, Vitkup D, Kaser A, Lehner PJ, Nathan JA. Dickson AS, et al. Among authors: wit n. Nat Commun. 2023 Aug 9;14(1):4816. doi: 10.1038/s41467-023-40541-1. Nat Commun. 2023. PMID: 37558666 Free PMC article.
Hypoxia drives HIF2-dependent reversible macrophage cell cycle entry.
Meng B, Zhao N, Mlcochova P, Ferreira IATM, Ortmann BM, Davis T, Wit N, Rehwinkel J, Cook S, Maxwell PH, Nathan JA, Gupta RK. Meng B, et al. Among authors: wit n. Cell Rep. 2024 Jul 23;43(7):114471. doi: 10.1016/j.celrep.2024.114471. Epub 2024 Jul 11. Cell Rep. 2024. PMID: 38996069 Free article.
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.
Bertlin JAC, Pauzaite T, Liang Q, Wit N, Williamson JC, Sia JJ, Matheson NJ, Ortmann BM, Mitchell TJ, Speak AO, Zhang Q, Nathan JA. Bertlin JAC, et al. Among authors: wit n. bioRxiv [Preprint]. 2024 Sep 6:2024.09.03.610968. doi: 10.1101/2024.09.03.610968. bioRxiv. 2024. PMID: 39282259 Free PMC article. Preprint.
Amino acid dependent formaldehyde metabolism in mammals.
Pietzke M, Burgos-Barragan G, Wit N, Tait-Mulder J, Sumpton D, Mackay GM, Patel KJ, Vazquez A. Pietzke M, et al. Among authors: wit n. Commun Chem. 2020 Jun 16;3(1):78. doi: 10.1038/s42004-020-0324-z. Commun Chem. 2020. PMID: 36703413 Free PMC article.
Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction.
Hansen CE, Vacondio D, van der Molen L, Jüttner AA, Fung WK, Karsten M, van Het Hof B, Fontijn RD, Kooij G, Witte ME, Roks AJM, de Vries HE, Mulder I, de Wit NM. Hansen CE, et al. Among authors: de wit nm. Cell Death Dis. 2025 Jan 3;16(1):1. doi: 10.1038/s41419-024-07306-0. Cell Death Dis. 2025. PMID: 39753531 Free PMC article.
408 results