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Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages.
Ghany LMAA, Beshay BY, Youssef Moustafa AM, Maghrabi AHA, Ali EHK, Saleem RM, Zaki I, Ryad N. Ghany LMAA, et al. Among authors: zaki i. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2243551. doi: 10.1080/14756366.2023.2243551. J Enzyme Inhib Med Chem. 2023. PMID: 37558232 Free PMC article.
Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.
Mourad MAE, Abo Elmaaty A, Zaki I, Mourad AAE, Hofni A, Khodir AE, Aboubakr EM, Elkamhawy A, Roh EJ, Al-Karmalawy AA. Mourad MAE, et al. Among authors: zaki i. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2205043. doi: 10.1080/14756366.2023.2205043. J Enzyme Inhib Med Chem. 2023. PMID: 37165800 Free PMC article.
Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues.
Fayad E, Altalhi SA, Abualnaja MM, Alrohaimi AH, Elsaid FG, Abu Almaaty AH, Saleem RM, Bazuhair MA, Ahmed Maghrabi AH, Beshay BY, Zaki I. Fayad E, et al. Among authors: zaki i. ACS Omega. 2023 Oct 9;8(41):38394-38405. doi: 10.1021/acsomega.3c05051. eCollection 2023 Oct 17. ACS Omega. 2023. PMID: 37867686 Free PMC article.
Design, synthesis and antiproliferative screening of newly synthesized coumarin-acrylamide hybrids as potential cytotoxic and apoptosis inducing agents.
Abd El-Lateef HM, Abdel Ghany LMA, Saleem RM, Ahmed Maghrabi AH, Yahya Alahdal MA, Khalifa Ali EH, Beshay BY, Zaki I, Masoud RE. Abd El-Lateef HM, et al. Among authors: zaki i. RSC Adv. 2023 Nov 6;13(46):32547-32557. doi: 10.1039/d3ra06644d. eCollection 2023 Oct 31. RSC Adv. 2023. PMID: 37936638 Free PMC article.
95 results