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The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.
Sanchez JE, Noor S, Sun MS, Zimmerly J, Pasmay A, Sanchez JJ, Vanderwall AG, Haynes MK, Sklar LA, Escalona PR, Milligan ED. Sanchez JE, et al. Among authors: sanchez jj. Neurosci Lett. 2023 Sep 25;814:137419. doi: 10.1016/j.neulet.2023.137419. Epub 2023 Aug 7. Neurosci Lett. 2023. PMID: 37558176 Free PMC article.
Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy.
Noor S, Pritha AN, Pasmay AA, Sanchez JE, Sanchez JJ, Fernandez-Oropeza AK, Sun MS, Dell'Orco M, Davies S, Savage DD, Mellios N, Milligan ED. Noor S, et al. Among authors: sanchez jj, sanchez je. Front Neurosci. 2023 Jun 9;17:1180308. doi: 10.3389/fnins.2023.1180308. eCollection 2023. Front Neurosci. 2023. PMID: 37360167 Free PMC article.
The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions.
Noor S, Sanchez JJ, Sun MS, Pervin Z, Sanchez JE, Havard MA, Epler LT, Nysus MV, Norenberg JP, Wagner CR, Davies S, Wagner JL, Savage DD, Jantzie LL, Mellios N, Milligan ED. Noor S, et al. Among authors: sanchez jj, sanchez je. Brain Behav Immun. 2020 Jul;87:339-358. doi: 10.1016/j.bbi.2020.01.002. Epub 2020 Jan 7. Brain Behav Immun. 2020. PMID: 31918004 Free PMC article.
Basic Science and Pathogenesis.
Gu T, Gomez L, Mews M, Whitehead PL, Hamilton-Nelson KL, Sanchez JJ, Adams LD, Mena PR, Starks TD, Silva-Vergara C, Illanes-Manrique MZ, Cuccaro ML, Vance JM, Cornejo-Olivas M, Byrd GS, Feliciano-Astacio BE, Haines JL, Beecham G, Pericak-Vance MA, Bush WS, Griswold AJ. Gu T, et al. Among authors: sanchez jj. Alzheimers Dement. 2024 Dec;20 Suppl 1:e092713. doi: 10.1002/alz.092713. Alzheimers Dement. 2024. PMID: 39751309
Basic Science and Pathogenesis.
Rajabli F, Aguiar-Pulido V, Scott K, Feliciano-Astacio BE, Hamilton-Nelson KL, Adams LD, Mena PR, Celis K, Sanchez JJ, Whitehead PL, Prough MB, Acosta H, McInerney KF, Vance JM, Cuccaro ML, Beecham GW Jr, Pericak-Vance MA. Rajabli F, et al. Among authors: sanchez jj. Alzheimers Dement. 2024 Dec;20 Suppl 1:e091886. doi: 10.1002/alz.091886. Alzheimers Dement. 2024. PMID: 39751275
Basic Science and Pathogenesis.
Wheeler NR, Mews M, Gu T, Gomez L, Whitehead PL, Hamilton-Nelson KL, Sanchez JJ, Adams LD, Mena PR, Starks TD, Silva C, Illanes-Manrique M, Cuccaro ML, Vance JM, Cornejo-Olivas M, Byrd GS, Feliciano-Astacio BE, Haines JL, Beecham G, Pericak-Vance MA, Griswold AJ, Bush WS. Wheeler NR, et al. Among authors: sanchez jj. Alzheimers Dement. 2024 Dec;20 Suppl 1:e093307. doi: 10.1002/alz.093307. Alzheimers Dement. 2024. PMID: 39750931
352 results