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The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.
Sanchez JE, Noor S, Sun MS, Zimmerly J, Pasmay A, Sanchez JJ, Vanderwall AG, Haynes MK, Sklar LA, Escalona PR, Milligan ED. Sanchez JE, et al. Among authors: pasmay a. Neurosci Lett. 2023 Sep 25;814:137419. doi: 10.1016/j.neulet.2023.137419. Epub 2023 Aug 7. Neurosci Lett. 2023. PMID: 37558176 Free PMC article.
Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy.
Noor S, Pritha AN, Pasmay AA, Sanchez JE, Sanchez JJ, Fernandez-Oropeza AK, Sun MS, Dell'Orco M, Davies S, Savage DD, Mellios N, Milligan ED. Noor S, et al. Among authors: pasmay aa. Front Neurosci. 2023 Jun 9;17:1180308. doi: 10.3389/fnins.2023.1180308. eCollection 2023. Front Neurosci. 2023. PMID: 37360167 Free PMC article.
Prenatal alcohol exposure promotes NLRP3 inflammasome-dependent immune actions following morphine treatment and paradoxically prolongs nerve injury-induced pathological pain in female mice.
Noor S, Sun MS, Pasmay AA, Pritha AN, Ruffaner-Hanson CD, Nysus MV, Jimenez DC, Murphy M, Savage DD, Valenzuela CF, Milligan ED. Noor S, et al. Among authors: pasmay aa. Alcohol Clin Exp Res (Hoboken). 2023 Dec;47(12):2262-2277. doi: 10.1111/acer.15214. Epub 2023 Nov 5. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 38151779 Free PMC article.