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The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.
Sanchez JE, Noor S, Sun MS, Zimmerly J, Pasmay A, Sanchez JJ, Vanderwall AG, Haynes MK, Sklar LA, Escalona PR, Milligan ED. Sanchez JE, et al. Among authors: milligan ed. Neurosci Lett. 2023 Sep 25;814:137419. doi: 10.1016/j.neulet.2023.137419. Epub 2023 Aug 7. Neurosci Lett. 2023. PMID: 37558176 Free PMC article.
Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy.
Noor S, Pritha AN, Pasmay AA, Sanchez JE, Sanchez JJ, Fernandez-Oropeza AK, Sun MS, Dell'Orco M, Davies S, Savage DD, Mellios N, Milligan ED. Noor S, et al. Among authors: milligan ed. Front Neurosci. 2023 Jun 9;17:1180308. doi: 10.3389/fnins.2023.1180308. eCollection 2023. Front Neurosci. 2023. PMID: 37360167 Free PMC article.
Prenatal alcohol exposure alters mRNA expression for stress peptides, glucocorticoid receptor function and immune factors in acutely stressed neonatal brain.
Ruffaner-Hanson CD, Fernandez-Oropeza AK, Sun MS, Caldwell KK, Allan AM, Savage DD, Valenzuela CF, Noor S, Milligan ED. Ruffaner-Hanson CD, et al. Among authors: milligan ed. Front Neurosci. 2023 Jun 23;17:1203557. doi: 10.3389/fnins.2023.1203557. eCollection 2023. Front Neurosci. 2023. PMID: 37425005 Free PMC article.
Prenatal alcohol exposure promotes NLRP3 inflammasome-dependent immune actions following morphine treatment and paradoxically prolongs nerve injury-induced pathological pain in female mice.
Noor S, Sun MS, Pasmay AA, Pritha AN, Ruffaner-Hanson CD, Nysus MV, Jimenez DC, Murphy M, Savage DD, Valenzuela CF, Milligan ED. Noor S, et al. Among authors: milligan ed. Alcohol Clin Exp Res (Hoboken). 2023 Dec;47(12):2262-2277. doi: 10.1111/acer.15214. Epub 2023 Nov 5. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 38151779 Free PMC article.
The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure.
Ruffaner-Hanson C, Noor S, Sun MS, Solomon E, Marquez LE, Rodriguez DE, Allan AM, Caldwell KK, Bakhireva LN, Milligan ED. Ruffaner-Hanson C, et al. Among authors: milligan ed. Exp Neurol. 2022 Sep;355:114121. doi: 10.1016/j.expneurol.2022.114121. Epub 2022 May 20. Exp Neurol. 2022. PMID: 35605668 Free PMC article. Review.
Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG.
Wilkerson JL, Alberti LB, Thakur GA, Makriyannis A, Milligan ED. Wilkerson JL, et al. Among authors: milligan ed. Brain Res. 2022 Jan 1;1774:147721. doi: 10.1016/j.brainres.2021.147721. Epub 2021 Nov 10. Brain Res. 2022. PMID: 34774500 Free PMC article.
79 results