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The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.
Sanchez JE, Noor S, Sun MS, Zimmerly J, Pasmay A, Sanchez JJ, Vanderwall AG, Haynes MK, Sklar LA, Escalona PR, Milligan ED. Sanchez JE, et al. Among authors: haynes mk. Neurosci Lett. 2023 Sep 25;814:137419. doi: 10.1016/j.neulet.2023.137419. Epub 2023 Aug 7. Neurosci Lett. 2023. PMID: 37558176 Free PMC article.
FRET detection of lymphocyte function-associated antigen-1 conformational extension.
Chigaev A, Smagley Y, Haynes MK, Ursu O, Bologa CG, Halip L, Oprea T, Waller A, Carter MB, Zhang Y, Wang W, Buranda T, Sklar LA. Chigaev A, et al. Among authors: haynes mk. Mol Biol Cell. 2015 Jan 1;26(1):43-54. doi: 10.1091/mbc.E14-06-1050. Epub 2014 Nov 5. Mol Biol Cell. 2015. PMID: 25378583 Free PMC article.
High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.
Haynes MK, Garcia M, Peters R, Waller A, Tedesco P, Ursu O, Bologa CG, Santos RG, Pinilla C, Wu TH, Lovchik JA, Oprea TI, Sklar LA, Tegos GP. Haynes MK, et al. Methods Mol Biol. 2018;1700:293-318. doi: 10.1007/978-1-4939-7454-2_16. Methods Mol Biol. 2018. PMID: 29177837
Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.
Lopez-Ramirez MA, McCurdy S, Li W, Haynes MK, Hale P, Francisco K, Oukoloff K, Bautista M, Choi CHJ, Sun H, Gongol B, Shyy JY, Ballatore C, Sklar LA, Gingras AR. Lopez-Ramirez MA, et al. Among authors: haynes mk. FASEB Bioadv. 2021 Feb 18;3(5):334-355. doi: 10.1096/fba.2020-00141. eCollection 2021 May. FASEB Bioadv. 2021. PMID: 33977234 Free PMC article.
29 results