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Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome.
Ding WY, Kuzmuk V, Hunter S, Lay A, Hayes B, Beesley M, Rollason R, Hurcombe JA, Barrington F, Masson C, Cathery W, May C, Tuffin J, Roberts T, Mollet G, Chu CJ, McIntosh J, Coward RJ, Antignac C, Nathwani A, Welsh GI, Saleem MA. Ding WY, et al. Among authors: rollason r. Sci Transl Med. 2023 Aug 9;15(708):eabc8226. doi: 10.1126/scitranslmed.abc8226. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556557
MAGI2 Mutations Cause Congenital Nephrotic Syndrome.
Bierzynska A, Soderquest K, Dean P, Colby E, Rollason R, Jones C, Inward CD, McCarthy HJ, Simpson MA, Lord GM, Williams M, Welsh GI, Koziell AB, Saleem MA; NephroS; UK study of Nephrotic Syndrome. Bierzynska A, et al. Among authors: rollason r. J Am Soc Nephrol. 2017 May;28(5):1614-1621. doi: 10.1681/ASN.2016040387. Epub 2016 Dec 8. J Am Soc Nephrol. 2017. PMID: 27932480 Free PMC article.
Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.
Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Østergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM. Lay AC, et al. Among authors: rollason r. Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29. Diabetologia. 2017. PMID: 28852804 Free PMC article.
IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes.
Lay AC, Hale LJ, Stowell-Connolly H, Pope RJP, Nair V, Ju W, Marquez E, Rollason R, Hurcombe JA, Hayes B, Roberts T, Gillam L, Allington J, Nelson RG, Kretzler M, Holly JMP, Perks CM, McArdle CA, Welsh GI, Coward RJM. Lay AC, et al. Among authors: rollason r. Diabetologia. 2021 Jul;64(7):1690-1702. doi: 10.1007/s00125-021-05427-1. Epub 2021 Mar 24. Diabetologia. 2021. PMID: 33758952 Free PMC article.
A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.
Kuzmuk V, Pranke I, Rollason R, Butler M, Ding WY, Beesley M, Waters AM, Coward RJ, Sessions R, Tuffin J, Foster RR, Mollet G, Antignac C, Edelman A, Welsh GI, Saleem MA. Kuzmuk V, et al. Among authors: rollason r. Kidney Int. 2024 Apr;105(4):744-758. doi: 10.1016/j.kint.2023.11.006. Epub 2023 Nov 22. Kidney Int. 2024. PMID: 37995908 Free article.
CD317/tetherin is an organiser of membrane microdomains.
Billcliff PG, Rollason R, Prior I, Owen DM, Gaus K, Banting G. Billcliff PG, et al. Among authors: rollason r. J Cell Sci. 2013 Apr 1;126(Pt 7):1553-64. doi: 10.1242/jcs.112953. Epub 2013 Feb 1. J Cell Sci. 2013. PMID: 23378022 Free PMC article.
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