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Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.
Aguilar R, Khan L, Arslanovic N, Birmingham K, Kasliwal K, Posnikoff S, Chakraborty U, Hickman AR, Watson R, Ezell RJ, Willis HE, Cowles MW, Garner R, Shim A, Gutierrez I, Marunde MR, Keogh MC, Tyler JK. Aguilar R, et al. Among authors: keogh mc. Res Sq [Preprint]. 2023 Jul 28:rs.3.rs-3182883. doi: 10.21203/rs.3.rs-3182883/v1. Res Sq. 2023. PMID: 37546815 Free PMC article. Preprint.
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.
Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, Horth C, McGuire JT, Xu X, Nikbakht H, Lemiesz AE, Marchione DM, Marunde MR, Meiners MJ, Cheek MA, Keogh MC, Bareke E, Djedid A, Harutyunyan AS, Jabado N, Garcia BA, Li H, Allis CD, Majewski J, Lu C. Weinberg DN, et al. Among authors: keogh mc. Nature. 2019 Sep;573(7773):281-286. doi: 10.1038/s41586-019-1534-3. Epub 2019 Sep 4. Nature. 2019. PMID: 31485078 Free PMC article.
Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma.
Thålin C, Aguilera K, Hall NW, Marunde MR, Burg JM, Rosell A, Daleskog M, Månsson M, Hisada Y, Meiners MJ, Sun ZW, Whelihan MF, Cheek MA, Howard SA, Saxena-Beem S, Noubouossie DF, Key NS, Sheikh SZ, Keogh MC, Cowles MW, Lundström S, Mackman N, Wallén H, Johnstone AL. Thålin C, et al. Among authors: keogh mc. J Thromb Haemost. 2020 Oct;18(10):2732-2743. doi: 10.1111/jth.15003. Epub 2020 Aug 8. J Thromb Haemost. 2020. PMID: 32654410 Free PMC article.
Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain.
Lloyd JT, McLaughlin K, Lubula MY, Gay JC, Dest A, Gao C, Phillips M, Tonelli M, Cornilescu G, Marunde MR, Evans CM, Boyson SP, Carlson S, Keogh MC, Markley JL, Frietze S, Glass KC. Lloyd JT, et al. Among authors: keogh mc. J Med Chem. 2020 Nov 12;63(21):12799-12813. doi: 10.1021/acs.jmedchem.0c01178. Epub 2020 Oct 21. J Med Chem. 2020. PMID: 33084328 Free PMC article.
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1.
Thomas JF, Valencia-Sánchez MI, Tamburri S, Gloor SL, Rustichelli S, Godínez-López V, De Ioannes P, Lee R, Abini-Agbomson S, Gretarsson K, Burg JM, Hickman AR, Sun L, Gopinath S, Taylor HF, Sun ZW, Ezell RJ, Vaidya A, Meiners MJ, Cheek MA, Rice WJ, Svetlov V, Nudler E, Lu C, Keogh MC, Pasini D, Armache KJ. Thomas JF, et al. Among authors: keogh mc. Sci Adv. 2023 Aug 9;9(32):eadg9832. doi: 10.1126/sciadv.adg9832. Epub 2023 Aug 9. Sci Adv. 2023. PMID: 37556531 Free PMC article.
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Gretarsson KH, Abini-Agbomson S, Gloor SL, Weinberg DN, McCuiston JL, Kumary VUS, Hickman AR, Sahu V, Lee R, Xu X, Lipieta N, Flashner S, Adeleke OA, Popova IK, Taylor HF, Noll K, Windham CL, Maryanski DN, Venters BJ, Nakagawa H, Keogh MC, Armache KJ, Lu C. Gretarsson KH, et al. Among authors: keogh mc. Sci Adv. 2024 Aug 30;10(35):eadp0975. doi: 10.1126/sciadv.adp0975. Epub 2024 Aug 28. Sci Adv. 2024. PMID: 39196936 Free PMC article.
Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.
Shah RN, Grzybowski AT, Cornett EM, Johnstone AL, Dickson BM, Boone BA, Cheek MA, Cowles MW, Maryanski D, Meiners MJ, Tiedemann RL, Vaughan RM, Arora N, Sun ZW, Rothbart SB, Keogh MC, Ruthenburg AJ. Shah RN, et al. Among authors: keogh mc. Mol Cell. 2018 Oct 4;72(1):162-177.e7. doi: 10.1016/j.molcel.2018.08.015. Epub 2018 Sep 20. Mol Cell. 2018. PMID: 30244833 Free PMC article.
66 results