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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.
Iyer AA, Hosamani I, Nguyen JD, Cai T, Singh S, McGovern MM, Beyer L, Zhang H, Jen HI, Yousaf R, Birol O, Sun JJ, Ray RS, Raphael Y, Segil N, Groves AK. Iyer AA, et al. Among authors: birol o. Elife. 2022 Nov 29;11:e79712. doi: 10.7554/eLife.79712. Elife. 2022. PMID: 36445327 Free PMC article.