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In vivo biomarkers of GABAergic function in epileptic rats treated with the GAT-1 inhibitor E2730.
Ali I, Jupp B, Hudson MR, Major B, Silva J, Yamakawa GR, Casillas-Espinosa PM, Braine E, Thergarajan P, Haskali MB, Vivash L, Brkljaca R, Shultz SR, Kwan P, Fukushima K, Sachdev P, Cheng JY, Mychasiuk R, Jones NC, Wright DK, OBrien TJ. Ali I, et al. Among authors: thergarajan p. Epilepsia. 2024 Nov;65(11):3376-3390. doi: 10.1111/epi.18119. Epub 2024 Sep 20. Epilepsia. 2024. PMID: 39302665
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy.
Ali I, Silva J, Casillas-Espinosa PM, Braine E, Yamakawa GR, Hudson MR, Brady RD, Major B, Thergarajan P, Haskali MB, Wright DK, Jupp B, Vivash L, Shultz SR, Mychasiuk R, Kwan P, Jones NC, Fukushima K, Sachdev P, Cheng JY, O'Brien TJ. Ali I, et al. Among authors: thergarajan p. Epilepsia. 2023 Oct;64(10):2806-2817. doi: 10.1111/epi.17735. Epub 2023 Aug 11. Epilepsia. 2023. PMID: 37539645