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Page 1
WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.
Rialdi A, Duffy M, Scopton AP, Fonseca F, Zhao JN, Schwarz M, Molina-Sanchez P, Mzoughi S, Arceci E, Abril-Fornaguera J, Meadows A, Ruiz de Galarreta M, Torre D, Reyes K, Lim YT, Rosemann F, Khan ZM, Mohammed K, Wang X, Yu X, Lakshmanan M, Rajarethinam R, Tan SY, Jin J, Villanueva A, Michailidis E, De Jong YP, Rice CM, Marazzi I, Hasson D, Llovet JM, Sobota RM, Lujambio A, Guccione E, Dar AC. Rialdi A, et al. Among authors: scopton ap. Nat Cancer. 2023 Aug;4(8):1157-1175. doi: 10.1038/s43018-023-00609-9. Epub 2023 Aug 3. Nat Cancer. 2023. PMID: 37537299 Free PMC article.
Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.
Yu JX, Craig AJ, Duffy ME, Villacorta-Martin C, Miguela V, Ruiz de Galarreta M, Scopton AP, Silber L, Maldonado AY, Rialdi A, Guccione E, Lujambio A, Villanueva A, Dar AC. Yu JX, et al. Among authors: scopton ap. Mol Cancer Ther. 2019 Sep;18(9):1506-1519. doi: 10.1158/1535-7163.MCT-18-0571. Epub 2019 Jun 18. Mol Cancer Ther. 2019. PMID: 31213506 Free PMC article.
Structural basis for the action of the drug trametinib at KSR-bound MEK.
Khan ZM, Real AM, Marsiglia WM, Chow A, Duffy ME, Yerabolu JR, Scopton AP, Dar AC. Khan ZM, et al. Among authors: scopton ap. Nature. 2020 Dec;588(7838):509-514. doi: 10.1038/s41586-020-2760-4. Epub 2020 Sep 14. Nature. 2020. PMID: 32927473 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35556798
Identification of novel functionally selective κ-opioid receptor scaffolds.
White KL, Scopton AP, Rives ML, Bikbulatov RV, Polepally PR, Brown PJ, Kenakin T, Javitch JA, Zjawiony JK, Roth BL. White KL, et al. Among authors: scopton ap. Mol Pharmacol. 2014 Jan;85(1):83-90. doi: 10.1124/mol.113.089649. Epub 2013 Oct 10. Mol Pharmacol. 2014. PMID: 24113749 Free PMC article.