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Page 1
Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: rahaim r. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.
Identification of potent small molecule inhibitors of SARS-CoV-2 entry.
Mediouni S, Mou H, Otsuka Y, Jablonski JA, Adcock RS, Batra L, Chung DH, Rood C, de Vera IMS, Rahaim R Jr, Ullah S, Yu X, Getmanenko YA, Kennedy NM, Wang C, Nguyen TT, Hull M, Chen E, Bannister TD, Baillargeon P, Scampavia L, Farzan M, Valente ST, Spicer TP. Mediouni S, et al. Among authors: rahaim r jr. SLAS Discov. 2022 Jan;27(1):8-19. doi: 10.1016/j.slasd.2021.10.012. Epub 2021 Oct 23. SLAS Discov. 2022. PMID: 35058179 Free PMC article.
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening.
Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R Jr, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Otsuka Y, et al. Among authors: rahaim r jr. SLAS Discov. 2021 Jan;26(1):113-121. doi: 10.1177/2472555220945283. Epub 2020 Jul 31. SLAS Discov. 2021. PMID: 32734807 Free PMC article.
Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.
Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, Malumbres M, Roussel MF, Roush WR, Hatten ME, Ayad NG. Penas C, et al. Among authors: rahaim rj. Cell Rep. 2015 Apr 14;11(2):249-60. doi: 10.1016/j.celrep.2015.03.016. Epub 2015 Apr 2. Cell Rep. 2015. PMID: 25843713 Free PMC article.
Casein kinase 1δ-dependent Wee1 protein degradation.
Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG. Penas C, et al. Among authors: rahaim rj. J Biol Chem. 2014 Jul 4;289(27):18893-903. doi: 10.1074/jbc.M114.547661. Epub 2014 May 9. J Biol Chem. 2014. PMID: 24817118 Free PMC article.
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.
Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: rahaim rj. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.
Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry.
Simanski S, Madoux F, Rahaim RJ, Chase P, Schurer S, Cameron M, Mercer BA, Hodder P, Roush WR, Ayad NG. Simanski S, et al. Among authors: rahaim rj. 2010 Sep 1 [updated 2013 Mar 22]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2010 Sep 1 [updated 2013 Mar 22]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23762957 Free Books & Documents. Review.
13 results