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Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, Zhang L, Goodwin A, Ledeboer A, Lam S, Ankoudinova I, Tran H, Scarlott N, Amora R, Surosky R, Miller JC, Robbins AB, Rebar EJ, Urnov FD, Holmes MC, Pooler AM, Riley B, Zhang HS, Hyman BT. Wegmann S, et al. Among authors: ledeboer a. Sci Adv. 2021 Mar 19;7(12):eabe1611. doi: 10.1126/sciadv.abe1611. Print 2021 Mar. Sci Adv. 2021. PMID: 33741591 Free PMC article.
AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction.
Yasuda M, Huston MW, Pagant S, Gan L, St Martin S, Sproul S, Richards D, Ballaron S, Hettini K, Ledeboer A, Falese L, Cao L, Lu Y, Holmes MC, Meyer K, Desnick RJ, Wechsler T. Yasuda M, et al. Among authors: ledeboer a. Mol Ther Methods Clin Dev. 2020 Jul 9;18:607-619. doi: 10.1016/j.omtm.2020.07.002. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32775495 Free PMC article.
Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.
Sloane E, Ledeboer A, Seibert W, Coats B, van Strien M, Maier SF, Johnson KW, Chavez R, Watkins LR, Leinwand L, Milligan ED, Van Dam AM. Sloane E, et al. Among authors: ledeboer a. Brain Behav Immun. 2009 Jan;23(1):92-100. doi: 10.1016/j.bbi.2008.09.004. Epub 2008 Sep 20. Brain Behav Immun. 2009. PMID: 18835435 Free PMC article.
A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
Kleibeuker W, Ledeboer A, Eijkelkamp N, Watkins LR, Maier SF, Zijlstra J, Heijnen CJ, Kavelaars A. Kleibeuker W, et al. Among authors: ledeboer a. Eur J Neurosci. 2007 Mar;25(6):1696-704. doi: 10.1111/j.1460-9568.2007.05423.x. Epub 2007 Apr 4. Eur J Neurosci. 2007. PMID: 17408432
40 results