Fujimori Y - Search Results

1

Efficacy of KPR-5714, a selective transient receptor potential melastatin 8 antagonist, on chronic psychological stress-induced bladder overactivity in male rats.

Watanabe S, Miyazaki S, Yumoto Y, Kobayashi JI, Fujimori Y. Watanabe S, et al. Among authors: fujimori y. Neurourol Urodyn. 2023 Nov;42(8):1812-1821. doi: 10.1002/nau.25255. Epub 2023 Jul 27. Neurourol Urodyn. 2023. PMID: 37498134

2

KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder afferent hyperactivity in rats.

Aizawa N, Fujimori Y, Kobayashi JI, Nakanishi O, Hirasawa H, Kume H, Homma Y, Igawa Y. Aizawa N, et al. Among authors: fujimori y. Neurourol Urodyn. 2018 Jun;37(5):1633-1640. doi: 10.1002/nau.23532. Epub 2018 Feb 21. Neurourol Urodyn. 2018. PMID: 29464762

3

KPR-5714, a selective transient receptor potential melastatin 8 antagonist, improves voiding dysfunction in rats with bladder overactivity but does not affect voiding behavior in normal rats.

Watanabe S, Fujimori Y, Matsuzawa A, Kobayashi JI, Hirasawa H, Mutai Y, Tanada F. Watanabe S, et al. Among authors: fujimori y. Neurourol Urodyn. 2022 Aug;41(6):1336-1343. doi: 10.1002/nau.24951. Epub 2022 May 10. Neurourol Urodyn. 2022. PMID: 35537073

4

KPR-5714, a Novel Transient Receptor Potential Melastatin 8 Antagonist, Improves Overactive Bladder via Inhibition of Bladder Afferent Hyperactivity in Rats.

Nakanishi O, Fujimori Y, Aizawa N, Hayashi T, Matsuzawa A, Kobayashi JI, Hirasawa H, Mutai Y, Tanada F, Igawa Y. Nakanishi O, et al. Among authors: fujimori y. J Pharmacol Exp Ther. 2020 May;373(2):239-247. doi: 10.1124/jpet.119.263616. Epub 2020 Feb 26. J Pharmacol Exp Ther. 2020. PMID: 32102918

5

Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β₃-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity.

Aizawa N, Fujimori Y, Nakanishi O, Hayashi T, Goi Y, Kobayashi JI, Fujita T. Aizawa N, et al. Among authors: fujimori y. Eur J Pharmacol. 2021 May 15;899:173995. doi: 10.1016/j.ejphar.2021.173995. Epub 2021 Mar 3. Eur J Pharmacol. 2021. PMID: 33675781

6

Synthesis and optimization of novel α-phenylglycinamides as selective TRPM8 antagonists.

Kobayashi JI, Hirasawa H, Ozawa T, Ozawa T, Takeda H, Fujimori Y, Nakanishi O, Kamada N, Ikeda T. Kobayashi JI, et al. Among authors: fujimori y. Bioorg Med Chem. 2017 Jan 15;25(2):727-742. doi: 10.1016/j.bmc.2016.11.049. Epub 2016 Nov 30. Bioorg Med Chem. 2017. PMID: 27964995

7

Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects.

Kobayashi JI, Hirasawa H, Fujimori Y, Nakanishi O, Kamada N, Ikeda T, Yamamoto A, Kanbe H. Kobayashi JI, et al. Among authors: fujimori y. Bioorg Med Chem. 2021 Jan 15;30:115903. doi: 10.1016/j.bmc.2020.115903. Epub 2020 Dec 3. Bioorg Med Chem. 2021. PMID: 33333445

8

Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor.

Shimizu K, Fujikura H, Fushimi N, Nishimura T, Tatani K, Katsuno K, Fujimori Y, Watanabe S, Hiratochi M, Nakabayashi T, Kamada N, Arakawa K, Hikawa H, Azumaya I, Isaji M. Shimizu K, et al. Among authors: fujimori y. Bioorg Med Chem. 2021 Mar 15;34:116033. doi: 10.1016/j.bmc.2021.116033. Epub 2021 Jan 22. Bioorg Med Chem. 2021. PMID: 33581390

9

Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation.

Inoue T, Takemura M, Fushimi N, Fujimori Y, Onozato T, Kurooka T, Asari T, Takeda H, Kobayashi M, Nishibe H, Isaji M. Inoue T, et al. Among authors: fujimori y. Eur J Pharmacol. 2017 Jul 5;806:25-31. doi: 10.1016/j.ejphar.2017.04.010. Epub 2017 Apr 11. Eur J Pharmacol. 2017. PMID: 28410751

10

Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats.

Fujimori Y, Katsuno K, Ojima K, Nakashima I, Nakano S, Ishikawa-Takemura Y, Kusama H, Isaji M. Fujimori Y, et al. Eur J Pharmacol. 2009 May 1;609(1-3):148-54. doi: 10.1016/j.ejphar.2009.03.007. Epub 2009 Mar 10. Eur J Pharmacol. 2009. PMID: 19281809

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