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hiPSC-derived cardiomyocytes as a model to study the role of small-conductance Ca2+-activated K+ (SK) ion channel variants associated with atrial fibrillation.
Babini H, Jiménez-Sábado V, Stogova E, Arslanova A, Butt M, Dababneh S, Asghari P, Moore EDW, Claydon TW, Chiamvimonvat N, Hove-Madsen L, Tibbits GF. Babini H, et al. Among authors: claydon tw. Front Cell Dev Biol. 2024 Jan 18;12:1298007. doi: 10.3389/fcell.2024.1298007. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38304423 Free PMC article. Review.
Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Venkateshappa R, Hunter DV, Muralidharan P, Nagalingam RS, Huen G, Faizi S, Luthra S, Lin E, Cheng YM, Hughes J, Khelifi R, Dhunna DP, Johal R, Sergeev V, Shafaattalab S, Julian LM, Poburko DT, Laksman Z, Tibbits GF, Claydon TW. Venkateshappa R, et al. Among authors: claydon tw. Cardiovasc Res. 2023 Nov 25;119(15):2522-2535. doi: 10.1093/cvr/cvad155. Cardiovasc Res. 2023. PMID: 37739930 Free PMC article.
Continuous Positive Airway Pressure plus Mandibular Advancement Therapy (PAPMAT): study protocol for an adaptive randomised crossover trial comparing the benefits and costs of combining two established treatments for obstructive sleep apnoea.
Law M, Villar S, Oscroft N, Stoneman V, Fox-Rushby J, Chiu YD, Steele J, Devine T, Francis C, Claydon T, Hill G, Lim KK, Rayner J, Williams M, Spires E, Quinnell T. Law M, et al. Among authors: claydon t. Trials. 2023 Jul 24;24(1):474. doi: 10.1186/s13063-023-07484-w. Trials. 2023. PMID: 37488626 Free PMC article.
CRISPR-Cas9-mediated Precise Knock-in Edits in Zebrafish Hearts.
Simpson KE, Faizi S, Venkateshappa R, Yip M, Johal R, Poburko D, Cheng YM, Hunter D, Lin E, Tibbits GF, Claydon TW. Simpson KE, et al. Among authors: claydon tw. J Vis Exp. 2022 Sep 13;(187). doi: 10.3791/64209. J Vis Exp. 2022. PMID: 36190280
Ion channel model reduction using manifold boundaries.
Whittaker DG, Wang J, Shuttleworth JG, Venkateshappa R, Kemp JM, Claydon TW, Mirams GR. Whittaker DG, et al. Among authors: claydon tw. J R Soc Interface. 2022 Aug;19(193):20220193. doi: 10.1098/rsif.2022.0193. Epub 2022 Aug 10. J R Soc Interface. 2022. PMID: 35946166 Free PMC article.
Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.
Simpson KE, Venkateshappa R, Pang ZK, Faizi S, Tibbits GF, Claydon TW. Simpson KE, et al. Among authors: claydon tw. Front Physiol. 2021 Jan 15;11:624129. doi: 10.3389/fphys.2020.624129. eCollection 2020. Front Physiol. 2021. PMID: 33519527 Free PMC article. Review.
The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.
Shi YP, Pang Z, Venkateshappa R, Gunawan M, Kemp J, Truong E, Chang C, Lin E, Shafaattalab S, Faizi S, Rayani K, Tibbits GF, Claydon VE, Claydon TW. Shi YP, et al. Among authors: claydon tw. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H251-H261. doi: 10.1152/ajpheart.00038.2020. Epub 2020 Jun 19. Am J Physiol Heart Circ Physiol. 2020. PMID: 32559136 Free article.
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