Hay MP - Search Results

1

Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisation.

Wong WW, O'Brien-Gortner SF, Anderson RF, Wilson WR, Hay MP, Dickson BD. Wong WW, et al. Among authors: hay mp. RSC Med Chem. 2023 Jun 8;14(7):1309-1330. doi: 10.1039/d3md00117b. eCollection 2023 Jul 20. RSC Med Chem. 2023. PMID: 37484567 Free PMC article.

2

Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.

Hay MP, Lee HH, Wilson WR, Roberts PB, Denny WA. Hay MP, et al. J Med Chem. 1995 May 26;38(11):1928-41. doi: 10.1021/jm00011a013. J Med Chem. 1995. PMID: 7783125

3

N-[2-(2-methyl-5-nitroimidazolyl)ethyl]-4-(2-nitroimidazolyl)butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug.

Moselen JW, Hay MP, Denny WA, Wilson WR. Moselen JW, et al. Among authors: hay mp. Cancer Res. 1995 Feb 1;55(3):574-80. Cancer Res. 1995. PMID: 7834627

4

Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers.

Hay MP, Wilson WR, Moselen JW, Palmer BD, Denny WA. Hay MP, et al. J Med Chem. 1994 Feb 4;37(3):381-91. doi: 10.1021/jm00029a010. J Med Chem. 1994. PMID: 8308864

5

Recent developments in the design of bioreductive drugs.

Denny WA, Wilson WR, Hay MP. Denny WA, et al. Among authors: hay mp. Br J Cancer Suppl. 1996 Jul;27:S32-8. Br J Cancer Suppl. 1996. PMID: 8763842 Free PMC article. Review. No abstract available.

6

Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1.

Batchelder RM, Wilson WR, Hay MP, Denny WA. Batchelder RM, et al. Among authors: hay mp. Br J Cancer Suppl. 1996 Jul;27:S52-6. Br J Cancer Suppl. 1996. PMID: 8763846 Free PMC article.

7

Nitroimidazole-based "extruded mustards' designed as reductively activated hypoxia-selective cytotoxins.

Hay MP, Denny WA, Wilson WR. Hay MP, et al. Anticancer Drug Des. 1996 Jul;11(5):383-402. Anticancer Drug Des. 1996. PMID: 8765531

8

A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.

Hay MP, Sykes BM, Denny WA, Wilson WR. Hay MP, et al. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2237-42. doi: 10.1016/s0960-894x(99)00381-9. Bioorg Med Chem Lett. 1999. PMID: 10465553

9

Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).

Hay MP, Wilson WR, Denny WA. Hay MP, et al. Bioorg Med Chem Lett. 1999 Dec 20;9(24):3417-22. doi: 10.1016/s0960-894x(99)00627-7. Bioorg Med Chem Lett. 1999. PMID: 10617083

10

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.

Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. J Med Chem. 2003 Jan 2;46(1):169-82. doi: 10.1021/jm020367+. J Med Chem. 2003. PMID: 12502371

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