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Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus.
López-Dávila AJ, Weber N, Nayak A, Fritz L, Moustafa KR, Gand LV, Wehry E, Kraft T, Thum T, Fernández J, Gutiérrez JM, Lomonte B. López-Dávila AJ, et al. Among authors: thum t. Pflugers Arch. 2023 Oct;475(10):1193-1202. doi: 10.1007/s00424-023-02840-w. Epub 2023 Jul 20. Pflugers Arch. 2023. PMID: 37474774 Free PMC article.
Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes.
Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knörr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Weber N, et al. Among authors: thum t. Basic Res Cardiol. 2016 Nov;111(6):68. doi: 10.1007/s00395-016-0587-9. Epub 2016 Oct 14. Basic Res Cardiol. 2016. PMID: 27743117
Preclinical development of a miR-132 inhibitor for heart failure treatment.
Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E, Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D, Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K, Thum T. Foinquinos A, et al. Among authors: thum t. Nat Commun. 2020 Jan 31;11(1):633. doi: 10.1038/s41467-020-14349-2. Nat Commun. 2020. PMID: 32005803 Free PMC article.
Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy.
Viereck J, Bührke A, Foinquinos A, Chatterjee S, Kleeberger JA, Xiao K, Janssen-Peters H, Batkai S, Ramanujam D, Kraft T, Cebotari S, Gueler F, Beyer AM, Schmitz J, Bräsen JH, Schmitto JD, Gyöngyösi M, Löser A, Hirt MN, Eschenhagen T, Engelhardt S, Bär C, Thum T. Viereck J, et al. Among authors: thum t. Eur Heart J. 2020 Sep 21;41(36):3462-3474. doi: 10.1093/eurheartj/ehaa519. Eur Heart J. 2020. PMID: 32657324 Free PMC article.
Myosin expression and contractile function are altered by replating stem cell-derived cardiomyocytes.
Osten F, Weber N, Wendland M, Holler T, Piep B, Kröhn S, Teske J, Bodenschatz AK, Devadas SB, Menge KS, Chatterjee S, Schwanke K, Kosanke M, Montag J, Thum T, Zweigerdt R, Kraft T, Iorga B, Meissner JD. Osten F, et al. Among authors: thum t. J Gen Physiol. 2023 Nov 6;155(11):e202313377. doi: 10.1085/jgp.202313377. Epub 2023 Sep 1. J Gen Physiol. 2023. PMID: 37656049 Free PMC article.
509 results