Roy J - Search Results

1

Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments.

Burguin A, Roy J, Ouellette G, Maltais R, Bherer J, Diorio C, Poirier D, Durocher F. Burguin A, et al. Among authors: roy j. J Clin Med. 2023 Jun 24;12(13):4241. doi: 10.3390/jcm12134241. J Clin Med. 2023. PMID: 37445276 Free PMC article.

2

A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.

Jegham H, Roy J, Maltais R, Desnoyers S, Poirier D. Jegham H, et al. Among authors: roy j. Invest New Drugs. 2012 Feb;30(1):176-85. doi: 10.1007/s10637-010-9548-6. Epub 2010 Oct 2. Invest New Drugs. 2012. PMID: 20890632

3

Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133.

Maltais R, Hospital A, Delhomme A, Roy J, Poirier D. Maltais R, et al. Among authors: roy j. Steroids. 2014 Apr;82:68-76. doi: 10.1016/j.steroids.2014.01.008. Epub 2014 Jan 30. Steroids. 2014. PMID: 24486462

4

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers.

Kenmogne LC, Ayan D, Roy J, Maltais R, Poirier D. Kenmogne LC, et al. Among authors: roy j. PLoS One. 2015 Dec 14;10(12):e0144890. doi: 10.1371/journal.pone.0144890. eCollection 2015. PLoS One. 2015. PMID: 26660672 Free PMC article.

5

Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents.

Talbot A, Maltais R, Kenmogne LC, Roy J, Poirier D. Talbot A, et al. Among authors: roy j. Steroids. 2016 Mar;107:55-64. doi: 10.1016/j.steroids.2015.12.019. Epub 2015 Dec 29. Steroids. 2016. PMID: 26742630

6

Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines.

Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Dutour R, et al. Among authors: roy j. Anticancer Agents Med Chem. 2018;18(10):1469-1481. doi: 10.2174/1871520618666180307130158. Anticancer Agents Med Chem. 2018. PMID: 29521249

7

Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model.

Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Perreault M, et al. Among authors: roy j. Invest New Drugs. 2019 Jun;37(3):431-440. doi: 10.1007/s10637-018-0643-4. Epub 2018 Jul 30. Invest New Drugs. 2019. PMID: 30062573

8

Antisulfatase, Osteogenic, and Anticancer Activities of Steroid Sulfatase Inhibitor EO-33 in Mice.

Poirier D, Roy J, Maltais R, Ayan D. Poirier D, et al. Among authors: roy j. J Med Chem. 2019 Jun 13;62(11):5512-5521. doi: 10.1021/acs.jmedchem.9b00382. Epub 2019 May 22. J Med Chem. 2019. PMID: 31062594

9

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.

Maltais R, Perreault M, Roy J, Poirier D. Maltais R, et al. Among authors: roy j. Eur J Med Chem. 2020 Feb 15;188:111990. doi: 10.1016/j.ejmech.2019.111990. Epub 2019 Dec 23. Eur J Med Chem. 2020. PMID: 31893547

10

A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models.

Poirier D, Roy J, Maltais R. Poirier D, et al. Among authors: roy j. Cancers (Basel). 2021 Apr 13;13(8):1841. doi: 10.3390/cancers13081841. Cancers (Basel). 2021. PMID: 33924352 Free PMC article.

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