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CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.
Montenont E, Bhatlekar S, Jacob S, Kosaka Y, Manne BK, Lee O, Parra-Izquierdo I, Tugolukova E, Tolley ND, Rondina MT, Bray PF, Rowley JW. Montenont E, et al. Among authors: jacob s. Blood Adv. 2021 May 11;5(9):2362-2374. doi: 10.1182/bloodadvances.2020004112. Blood Adv. 2021. PMID: 33944898 Free PMC article.
Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function.
Bhatlekar S, Jacob S, Manne BK, Guo L, Denorme F, Tugolukova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, O'Connell RM, Bray PF. Bhatlekar S, et al. Among authors: jacob s. Blood Cells Mol Dis. 2021 Dec;92:102624. doi: 10.1016/j.bcmd.2021.102624. Epub 2021 Nov 3. Blood Cells Mol Dis. 2021. PMID: 34775219 Free PMC article.
MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis.
Manne BK, Campbell RA, Bhatlekar S, Ajanel A, Denorme F, Portier I, Middleton EA, Tolley ND, Kosaka Y, Montenont E, Guo L, Rowley JW, Bray PF, Jacob S, Fukanaga R, Proud C, Weyrich AS, Rondina MT. Manne BK, et al. Among authors: jacob s. Blood. 2022 Dec 8;140(23):2477-2489. doi: 10.1182/blood.2022015568. Blood. 2022. PMID: 35930749 Free PMC article.
Platelet MHC class I mediates CD8+ T-cell suppression during sepsis.
Guo L, Shen S, Rowley JW, Tolley ND, Jia W, Manne BK, McComas KN, Bolingbroke B, Kosaka Y, Krauel K, Denorme F, Jacob SP, Eustes AS, Campbell RA, Middleton EA, He X, Brown SM, Morrell CN, Weyrich AS, Rondina MT. Guo L, et al. Among authors: jacob sp. Blood. 2021 Aug 5;138(5):401-416. doi: 10.1182/blood.2020008958. Blood. 2021. PMID: 33895821 Free PMC article.
2,673 results