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Page 1
Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation.
Kwaku GN, Jensen KN, Simaku P, Floyd DJ, Saelens JW, Reardon CM, Ward RA, Basham KJ, Hepworth OW, Vyas TD, Zamith-Miranda D, Nosanchuk JD, Vyas JM, Harding HB. Kwaku GN, et al. Among authors: ward ra. bioRxiv [Preprint]. 2025 Jan 3:2025.01.03.631181. doi: 10.1101/2025.01.03.631181. bioRxiv. 2025. PMID: 39803513 Free PMC article. Preprint.
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Thomson C, Braybrooke E, Colclough N, Davies NL, Floc'h N, Greenwood R, Guérot C, Hargreaves D, Johnstrom P, Khurana P, Kostomiris DH, Li S, Lister A, Lorthioir O, Martin S, McCoull W, McLean NJ, McWilliams L, Orme JP, Packer MJ, Pearson S, Swaih AM, Tentarelli S, Tucker MJ, Ward RA, Wilkinson S, Winlow P, Wood IL. Thomson C, et al. Among authors: ward ra. J Med Chem. 2024 Sep 28. doi: 10.1021/acs.jmedchem.4c01792. Online ahead of print. J Med Chem. 2024. PMID: 39340451
Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides.
Harding AT, Crossen AJ, Reedy JL, Basham KJ, Hepworth OW, Zhang Y, Shah VS, Harding HB, Surve MV, Simaku P, Kwaku GN, Jensen KN, Otto Y, Ward RA, Thompson GR, Klein BS, Rajagopal J, Sen P, Haber AL, Vyas JM. Harding AT, et al. Among authors: ward ra. bioRxiv [Preprint]. 2024 Sep 13:2024.09.09.612147. doi: 10.1101/2024.09.09.612147. bioRxiv. 2024. PMID: 39314271 Free PMC article. Preprint.
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Thomson C, Barton P, Braybrooke E, Colclough N, Dong Z, Evans L, Floc'h N, Guérot C, Hargreaves D, Khurana P, Li S, Li X, Lister A, McCoull W, McWilliams L, Orme JP, Packer MJ, Swaih AM, Ward RA, Winlow P, Ye Y. Thomson C, et al. Among authors: ward ra. J Med Chem. 2024 Jun 13;67(11):8988-9027. doi: 10.1021/acs.jmedchem.4c00227. Epub 2024 May 21. J Med Chem. 2024. PMID: 38770784
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR.
Pemberton N, Compagne N, Argyrou A, Evertsson E, Gunnarsson A, Kettle JG, Orme JP, Ward RA. Pemberton N, et al. Among authors: ward ra. ACS Med Chem Lett. 2024 Apr 5;15(5):583-589. doi: 10.1021/acsmedchemlett.3c00425. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746885
BTK inhibitor-induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α.
Vargas-Blanco DA, Hepworth OW, Basham KJ, Simaku P, Crossen AJ, Timmer KD, Hopke A, Brown Harding H, Vandal SR, Jensen KN, Floyd DJ, Reedy JL, Reardon C, Mansour MK, Ward RA, Irimia D, Abramson JS, Vyas JM. Vargas-Blanco DA, et al. Among authors: ward ra. JCI Insight. 2024 May 7;9(12):e176162. doi: 10.1172/jci.insight.176162. JCI Insight. 2024. PMID: 38713531 Free PMC article.
297 results