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Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Akkapeddi P, Hattori T, Khan I, Glasser E, Koide A, Ketavarapu G, Whaby M, Zuberi M, Teng KW, Lefler J, Maso L, Bang I, Ostrowski MC, O'Bryan JP, Koide S. Akkapeddi P, et al. Among authors: lefler j. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2302485120. doi: 10.1073/pnas.2302485120. Epub 2023 Jul 3. Proc Natl Acad Sci U S A. 2023. PMID: 37399416 Free PMC article.
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.
Khan I, Marelia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, Connor DM, Broome AM, Pécot T, Timmers C, Ostrowski MC, Koide S, O'Bryan JP. Khan I, et al. Among authors: lefler j. Small GTPases. 2022 Jan;13(1):114-127. doi: 10.1080/21541248.2021.1906621. Epub 2021 May 5. Small GTPases. 2022. PMID: 33949915 Free PMC article.
PTEN in cancer associated fibroblasts.
Lefler JE, Seward C, Ostrowski MC. Lefler JE, et al. Adv Cancer Res. 2022;154:203-226. doi: 10.1016/bs.acr.2022.01.002. Epub 2022 Mar 18. Adv Cancer Res. 2022. PMID: 35459470
PTEN in the Stroma.
Thies KA, Lefler JE, Leone G, Ostrowski MC. Thies KA, et al. Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):a036111. doi: 10.1101/cshperspect.a036111. Cold Spring Harb Perspect Med. 2019. PMID: 31427286 Free PMC article. Review.
The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.
Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G. Han L, et al. Among authors: lefler j. Nat Commun. 2023 Jan 3;14(1):1. doi: 10.1038/s41467-022-34464-6. Nat Commun. 2023. PMID: 36596776 Free PMC article.
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.
Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC. Lefler JE, et al. Life Sci Alliance. 2022 Jul 8;5(11):e202201460. doi: 10.26508/lsa.202201460. Print 2022 Nov. Life Sci Alliance. 2022. PMID: 35803738 Free PMC article.
Effects of peripartal rumen-derived direct-fed microbials supplementation on lactation performance, metabolism, ruminal fermentation, and microbial abundance in dairy cows.
Bulnes M, Bonilla J, Suazo M, Michelotti TC, Paz A, Lefler J, Marotz C, Embree M, Begalli G, Halfen J, Fernandes T, Trevisi E, Uddin ME, Osorio JS. Bulnes M, et al. Among authors: lefler j. J Dairy Sci. 2024 Dec 9:S0022-0302(24)01346-8. doi: 10.3168/jds.2024-25058. Online ahead of print. J Dairy Sci. 2024. PMID: 39662816 Free article.
39 results