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Page 1
NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression.
Takashima K, Lee DJ, Trovero MF, Rothi MH, Mistry M, Zhang Y, Li Z, Davis CP, Li Z, Natale J, Schmid E, Al Haddad J, Hoffmann GB, Dietmann S, Sui SH, Oshiumi H, Lieberman J, Greer EL. Takashima K, et al. Among authors: lieberman j. bioRxiv [Preprint]. 2023 Jun 13:2023.06.13.544862. doi: 10.1101/2023.06.13.544862. bioRxiv. 2023. PMID: 37397991 Free PMC article. Preprint.
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity.
Fontana P, Du G, Zhang Y, Zhang H, Vora SM, Hu JJ, Shi M, Tufan AB, Healy LB, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo HR, Agudo J, Lieberman J, Wu H. Fontana P, et al. Among authors: lieberman j. Cell. 2024 Oct 31;187(22):6165-6181.e22. doi: 10.1016/j.cell.2024.08.007. Epub 2024 Sep 6. Cell. 2024. PMID: 39243763
Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis.
Balasubramanian A, Ghimire L, Hsu AY, Kambara H, Liu X, Hasegawa T, Xu R, Tahir M, Yu H, Lieberman J, Luo HR. Balasubramanian A, et al. Among authors: lieberman j. bioRxiv [Preprint]. 2023 Feb 21:2023.02.21.529402. doi: 10.1101/2023.02.21.529402. bioRxiv. 2023. Update in: Sci Immunol. 2024 Apr 12;9(94):eadn1452. doi: 10.1126/sciimmunol.adn1452 PMID: 36865189 Free PMC article. Updated. Preprint.
ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation.
Du G, Healy LB, David L, Walker C, Fontana P, Dong Y, Devant P, Puthenveetil R, Ficarro SB, Banerjee A, Kagan JC, Lieberman J, Wu H. Du G, et al. Among authors: lieberman j. bioRxiv [Preprint]. 2023 Mar 7:2023.03.07.531538. doi: 10.1101/2023.03.07.531538. bioRxiv. 2023. Update in: Nature. 2024 Jun;630(8016):437-446. doi: 10.1038/s41586-024-07373-5 PMID: 36945424 Free PMC article. Updated. Preprint.
Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez S, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Sefik E, et al. Among authors: lieberman j. bioRxiv [Preprint]. 2022 Apr 1:2021.09.27.461948. doi: 10.1101/2021.09.27.461948. bioRxiv. 2022. Update in: Nature. 2022 Jun;606(7914):585-593. doi: 10.1038/s41586-022-04802-1 PMID: 34611663 Free PMC article. Updated. Preprint.
2,082 results