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A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture.
Andradi-Brown C, Wichers-Misterek JS, von Thien H, Höppner YD, Scholz JAM, Hansson H, Filtenborg Hocke E, Gilberger TW, Duffy MF, Lavstsen T, Baum J, Otto TD, Cunnington AJ, Bachmann A. Andradi-Brown C, et al. Among authors: hoppner yd. Elife. 2024 Jan 25;12:RP87726. doi: 10.7554/eLife.87726. Elife. 2024. PMID: 38270586 Free PMC article.
The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections.
Wichers-Misterek JS, Krumkamp R, Held J, von Thien H, Wittmann I, Höppner YD, Ruge JM, Moser K, Dara A, Strauss J, Esen M, Fendel R, Sulyok Z, Jeninga MD, Kremsner PG, Sim BKL, Hoffman SL, Duffy MF, Otto TD, Gilberger TW, Silva JC, Mordmüller B, Petter M, Bachmann A. Wichers-Misterek JS, et al. Among authors: hoppner yd. PLoS Pathog. 2023 Jun 29;19(6):e1011468. doi: 10.1371/journal.ppat.1011468. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37384799 Free PMC article.