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Page 1
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.
Chancellor A, Alan Simmons R, Khanolkar RC, Nosi V, Beshirova A, Berloffa G, Colombo R, Karuppiah V, Pentier JM, Tubb V, Ghadbane H, Suckling RJ, Page K, Crean RM, Vacchini A, De Gregorio C, Schaefer V, Constantin D, Gligoris T, Lloyd A, Hock M, Srikannathasan V, Robinson RA, Besra GS, van der Kamp MW, Mori L, Calogero R, Cole DK, De Libero G, Lepore M. Chancellor A, et al. Among authors: cole dk. J Exp Med. 2023 Sep 4;220(9):e20221939. doi: 10.1084/jem.20221939. Epub 2023 Jun 29. J Exp Med. 2023. PMID: 37382893 Free PMC article.
Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.
Dolton G, Lissina A, Skowera A, Ladell K, Tungatt K, Jones E, Kronenberg-Versteeg D, Akpovwa H, Pentier JM, Holland CJ, Godkin AJ, Cole DK, Neller MA, Miles JJ, Price DA, Peakman M, Sewell AK. Dolton G, et al. Among authors: cole dk. Clin Exp Immunol. 2014 Jul;177(1):47-63. doi: 10.1111/cei.12339. Clin Exp Immunol. 2014. PMID: 24673376 Free PMC article.
Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
Holland CJ, Crean RM, Pentier JM, de Wet B, Lloyd A, Srikannathasan V, Lissin N, Lloyd KA, Blicher TH, Conroy PJ, Hock M, Pengelly RJ, Spinner TE, Cameron B, Potter EA, Jeyanthan A, Molloy PE, Sami M, Aleksic M, Liddy N, Robinson RA, Harper S, Lepore M, Pudney CR, van der Kamp MW, Rizkallah PJ, Jakobsen BK, Vuidepot A, Cole DK. Holland CJ, et al. Among authors: cole dk. J Clin Invest. 2020 May 1;130(5):2673-2688. doi: 10.1172/JCI130562. J Clin Invest. 2020. PMID: 32310221 Free PMC article.
Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy.
Crean RM, MacLachlan BJ, Madura F, Whalley T, Rizkallah PJ, Holland CJ, McMurran C, Harper S, Godkin A, Sewell AK, Pudney CR, van der Kamp MW, Cole DK. Crean RM, et al. Among authors: cole dk. Mol Ther Oncolytics. 2020 Jul 31;18:443-456. doi: 10.1016/j.omto.2020.07.008. eCollection 2020 Sep 25. Mol Ther Oncolytics. 2020. PMID: 32913893 Free PMC article.
Engineering soluble T-cell receptors for therapy.
Robinson RA, McMurran C, McCully ML, Cole DK. Robinson RA, et al. Among authors: cole dk. FEBS J. 2021 Nov;288(21):6159-6173. doi: 10.1111/febs.15780. Epub 2021 Mar 10. FEBS J. 2021. PMID: 33624424 Free PMC article. Review.
Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Barber C, De Souza VA, Paterson RL, Martin-Urdiroz M, Mulakkal NC, Srikannathasan V, Connolly M, Phillips G, Foong-Leong T, Pengelly R, Karuppiah V, Grant T, Dembek M, Verma A, Gibbs-Howe D, Blicher TH, Knox A, Robinson RA, Cole DK, Leonard S. Barber C, et al. Among authors: cole dk. Eur J Immunol. 2022 Apr;52(4):618-632. doi: 10.1002/eji.202149745. Epub 2022 Feb 13. Eur J Immunol. 2022. PMID: 35108401 Free PMC article.
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen.
Poole A, Karuppiah V, Hartt A, Haidar JN, Moureau S, Dobrzycki T, Hayes C, Rowley C, Dias J, Harper S, Barnbrook K, Hock M, Coles C, Yang W, Aleksic M, Lin AB, Robinson R, Dukes JD, Liddy N, Van der Kamp M, Plowman GD, Vuidepot A, Cole DK, Whale AD, Chillakuri C. Poole A, et al. Among authors: cole dk. Nat Commun. 2022 Sep 10;13(1):5333. doi: 10.1038/s41467-022-32811-1. Nat Commun. 2022. PMID: 36088370 Free PMC article.
114 results