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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.
Rodina A, Xu C, Digwal CS, Joshi S, Patel Y, Santhaseela AR, Bay S, Merugu S, Alam A, Yan P, Yang C, Roychowdhury T, Panchal P, Shrestha L, Kang Y, Sharma S, Almodovar J, Corben A, Alpaugh ML, Modi S, Guzman ML, Fei T, Taldone T, Ginsberg SD, Erdjument-Bromage H, Neubert TA, Manova-Todorova K, Tsou MB, Young JC, Wang T, Chiosis G. Rodina A, et al. Among authors: young jc. Nat Commun. 2023 Jun 23;14(1):3742. doi: 10.1038/s41467-023-39241-7. Nat Commun. 2023. PMID: 37353488 Free PMC article.
Function and Chemotypes of Human Hsp70 Chaperones.
Shrestha L, Young JC. Shrestha L, et al. Among authors: young jc. Curr Top Med Chem. 2016;16(25):2812-28. doi: 10.2174/1568026616666160413142028. Curr Top Med Chem. 2016. PMID: 27072695 Review.
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Rodina A, et al. Among authors: young jc. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239008 Free PMC article.
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Taldone T, et al. Among authors: young jc. J Med Chem. 2014 Feb 27;57(4):1208-24. doi: 10.1021/jm401552y. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548239 Free PMC article.
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Kang Y, et al. Among authors: young jc. J Med Chem. 2014 Feb 27;57(4):1188-207. doi: 10.1021/jm401551n. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548207 Free PMC article.
Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.
Bagdany M, Veit G, Fukuda R, Avramescu RG, Okiyoneda T, Baaklini I, Singh J, Sovak G, Xu H, Apaja PM, Sattin S, Beitel LK, Roldan A, Colombo G, Balch W, Young JC, Lukacs GL. Bagdany M, et al. Among authors: young jc. Nat Commun. 2017 Aug 30;8(1):398. doi: 10.1038/s41467-017-00444-4. Nat Commun. 2017. PMID: 28855508 Free PMC article.
Membrane cholesterol as regulator of human rhomboid protease RHBDL4.
Paschkowsky S, Recinto SJ, Young JC, Bondar AN, Munter LM. Paschkowsky S, et al. Among authors: young jc. J Biol Chem. 2018 Oct 5;293(40):15556-15568. doi: 10.1074/jbc.RA118.002640. Epub 2018 Aug 24. J Biol Chem. 2018. PMID: 30143535 Free PMC article.
Hsp70 and DNAJA2 limit CFTR levels through degradation.
Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC. Kim Chiaw P, et al. Among authors: young jc. PLoS One. 2019 Aug 13;14(8):e0220984. doi: 10.1371/journal.pone.0220984. eCollection 2019. PLoS One. 2019. PMID: 31408507 Free PMC article.
406 results