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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.
Rodina A, Xu C, Digwal CS, Joshi S, Patel Y, Santhaseela AR, Bay S, Merugu S, Alam A, Yan P, Yang C, Roychowdhury T, Panchal P, Shrestha L, Kang Y, Sharma S, Almodovar J, Corben A, Alpaugh ML, Modi S, Guzman ML, Fei T, Taldone T, Ginsberg SD, Erdjument-Bromage H, Neubert TA, Manova-Todorova K, Tsou MB, Young JC, Wang T, Chiosis G. Rodina A, et al. Among authors: patel y. Nat Commun. 2023 Jun 23;14(1):3742. doi: 10.1038/s41467-023-39241-7. Nat Commun. 2023. PMID: 37353488 Free PMC article.
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Rodina A, et al. Among authors: patel y, patel mr, patel pd, patel hj. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239008 Free PMC article.
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Taldone T, et al. Among authors: patel y, patel mr, patel pd, patel hj. J Med Chem. 2014 Feb 27;57(4):1208-24. doi: 10.1021/jm401552y. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548239 Free PMC article.
Long-Term Efficacy and Safety of Danicopan as Add-On Therapy to Ravulizumab or Eculizumab in PNH With Significant EVH.
Kulasekararaj AG, Griffin M, Piatek CI, Shammo J, Nishimura JI, Patriquin CJ, Schrezenmeier H, Barcellini W, Panse JP, Gaya A, Patel Y, Liu P, Filippov G, Sicre de Fontbrune F, Risitano AM, Lee JW. Kulasekararaj AG, et al. Among authors: patel y. Blood. 2024 Dec 19:blood.2024026299. doi: 10.1182/blood.2024026299. Online ahead of print. Blood. 2024. PMID: 39700502
A robust benchmark for detecting low-frequency variants in the HG002 Genome In A Bottle NIST reference material.
Daniels CA, Abdulkadir A, Cleveland MH, McDaniel JH, Jáspez D, Rubio-Rodríguez LA, Muñoz-Barrera A, Lorenzo-Salazar JM, Flores C, Yoo B, Sahraeian SME, Wang Y, Rossi M, Visvanath A, Murray L, Chen WT, Catreux S, Han J, Mehio R, Parnaby G, Carroll A, Chang PC, Shafin K, Cook D, Kolesnikov A, Brambrink L, Mootor MFE, Patel Y, Yamaguchi TN, Boutros PC, Sienkiewicz K, Foox J, Mason CE, Lajoie BR, Ruiz-Perez CA, Kruglyak S, Zook JM, Olson ND. Daniels CA, et al. Among authors: patel y. bioRxiv [Preprint]. 2024 Dec 5:2024.12.02.625685. doi: 10.1101/2024.12.02.625685. bioRxiv. 2024. PMID: 39677813 Free PMC article. Preprint.
Pioneering Computational Culture Within Pharmacy Schools by Empowering Students With Data Science and Bioinformatics Skills.
Ronkowski C, Deshpande D, Sharma N, Vahed M, Patel YM, Gukasyan HJ, Wu M, Peng K, Church TD, Kim RE, Mirzaian E, Padula WV, Tomaszewski D, Ng TMH, Wong-Beringer A, Zaro J, Qato DM, Davies DL, Papadopoulos V, Mangul S. Ronkowski C, et al. Among authors: patel ym. Am J Pharm Educ. 2024 Dec 12:101341. doi: 10.1016/j.ajpe.2024.101341. Online ahead of print. Am J Pharm Educ. 2024. PMID: 39674347
1,015 results