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Page 1
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP. Lei Y, et al. Among authors: west lc, west ap. Cell. 2023 Jul 6;186(14):3013-3032.e22. doi: 10.1016/j.cell.2023.05.039. Epub 2023 Jun 22. Cell. 2023. PMID: 37352855 Free PMC article.
Mitochondria in innate immune responses.
West AP, Shadel GS, Ghosh S. West AP, et al. Nat Rev Immunol. 2011 Jun;11(6):389-402. doi: 10.1038/nri2975. Epub 2011 May 20. Nat Rev Immunol. 2011. PMID: 21597473 Free PMC article. Review.
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Rongvaux A, et al. Among authors: west ap. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. Cell. 2014. PMID: 25525875 Free PMC article.
Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.
Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. Thakar J, et al. Among authors: west ap. Aging (Albany NY). 2015 Jan;7(1):38-52. doi: 10.18632/aging.100720. Aging (Albany NY). 2015. PMID: 25596819 Free PMC article.
Mitochondrial DNA stress primes the antiviral innate immune response.
West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. West AP, et al. Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2. Nature. 2015. PMID: 25642965 Free PMC article.
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. Zhao B, et al. Among authors: west ap. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May 22. Nature. 2019. PMID: 31118511 Free PMC article.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Yambire KF, et al. Among authors: west ap. Elife. 2019 Dec 3;8:e51031. doi: 10.7554/eLife.51031. Elife. 2019. PMID: 31793879 Free PMC article.
195 results