Sitarik I - Search Results

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Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements.

Lan PD, Nissley DA, Sitarik I, Vu QV, Jiang Y, To P, Xia Y, Fried SD, Li MS, O'Brien EP. Lan PD, et al. Among authors: sitarik i. J Mol Biol. 2024 Mar 15;436(6):168487. doi: 10.1016/j.jmb.2024.168487. Epub 2024 Feb 9. J Mol Biol. 2024. PMID: 38341172 Free PMC article.

Non-covalent Lasso Entanglements in Folded Proteins: Prevalence, Functional Implications, and Evolutionary Significance.

Rana V, Sitarik I, Petucci J, Jiang Y, Song H, O'Brien EP. Rana V, et al. Among authors: sitarik i. J Mol Biol. 2024 Mar 15;436(6):168459. doi: 10.1016/j.jmb.2024.168459. Epub 2024 Jan 30. J Mol Biol. 2024. PMID: 38296158 Free PMC article.

How soluble misfolded proteins bypass chaperones at the molecular level.

Halder R, Nissley DA, Sitarik I, Jiang Y, Rao Y, Vu QV, Li MS, Pritchard J, O'Brien EP. Halder R, et al. Among authors: sitarik i. Nat Commun. 2023 Jun 21;14(1):3689. doi: 10.1038/s41467-023-38962-z. Nat Commun. 2023. PMID: 37344452 Free PMC article.

How synonymous mutations alter enzyme structure and function over long timescales.

Jiang Y, Neti SS, Sitarik I, Pradhan P, To P, Xia Y, Fried SD, Booker SJ, O'Brien EP. Jiang Y, et al. Among authors: sitarik i. Nat Chem. 2023 Mar;15(3):308-318. doi: 10.1038/s41557-022-01091-z. Epub 2022 Dec 5. Nat Chem. 2023. PMID: 36471044 Free PMC article.

Pulse labeling reveals the tail end of protein folding by proteome profiling.

Zhu M, Kuechler ER, Wong RWK, Calabrese G, Sitarik IM, Rana V, Stoynov N, O'Brien EP, Gsponer J, Mayor T. Zhu M, et al. Among authors: sitarik im. Cell Rep. 2022 Jul 19;40(3):111096. doi: 10.1016/j.celrep.2022.111096. Cell Rep. 2022. PMID: 35858568 Free PMC article.

Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional.

Nissley DA, Jiang Y, Trovato F, Sitarik I, Narayan KB, To P, Xia Y, Fried SD, O'Brien EP. Nissley DA, et al. Among authors: sitarik i. Nat Commun. 2022 Jun 2;13(1):3081. doi: 10.1038/s41467-022-30548-5. Nat Commun. 2022. PMID: 35654797 Free PMC article.

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